AI Article Synopsis
- The study investigated the hepatoprotective effects of Lycium chinense Miller fruit extract and its component betaine on rats exposed to carbon tetrachloride (CCl4), which causes liver damage.
- The LC fruit extract significantly reduced levels of liver enzymes (ALT and AST) and restored antioxidant enzyme levels while lowering inflammatory substances (iNOS and COX-1/COX-2) in the rats.
- Substituting betaine for the LC extract produced similar protective effects, indicating that both the extract and betaine help alleviate liver damage through enhanced antioxidant activity and reduced inflammation.
Article Abstract
The hepatoprotective activities of Lycium chinense Miller (LC) fruit extract and its component betaine were investigated under carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The treatment of LC fruit extract significantly suppressed the increase of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the sera of CCl4 injured rats, and restored the decreased levels of anti-oxidant enzymes such as total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and suppressed the expression of inflammatory mediators including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-1 and -2. To visualize the potential activity of betaine, a component of LC fruit, betaine was substituted for LC extract in CCl4 injured rats. The biochemical profile in CCl4 injured rats co-treated with betaine matched those of LC fruit treated CCl4 injured rats. The ameliorative effects of LC extract, as well as betaine, were also confirmed by histopathological examination. Collectively, the present findings imply that LC fruit, via its component betaine, mitigate CCl4-induced hepatic injury by increasing antioxidative activity and decreasing inflammatory mediators including iNOS and COX-1/COX-2.
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| http://dx.doi.org/10.1016/j.acthis.2014.05.004 | DOI Listing |
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