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SMP30 Alleviates Oxidative Stress and Regulates Ca-ATPase Activity in UVR-B-Induced Cataracts in Rats.
Curr Eye Res
December 2024
Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Purpose: Oxidative stress, ultraviolet radiation, and calcium imbalance are key components in the onset and advancement of cataract, which continue to be the leading cause of blindness globally. An important newly discovered aging maker, Senescence marker protein 30 (SMP30) regulates calcium and participates in mitigating oxidative stress damage. Here, we examined the beneficial role of SMP30 in protecting against ultraviolet radiation type B (UVR-B)-induced cataract in rats.
View Article and Find Full Text PDFTowards Clinical Application: Calcium Waves for In Vitro Qualitative Assessment of Propagated Primary Human Corneal Endothelial Cells.
Cells
December 2024
Tissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Corneal endothelium cells (CECs) regulate corneal hydration between the leaky barrier of the corneal endothelium and the ionic pumps on the surface of CECs. As CECs do not regenerate, loss of CECs leads to poor vision and corneal blindness. Corneal transplant is the only treatment option; however, there is a severe shortage of donor corneas globally.
View Article and Find Full Text PDFNeuropsin, TRPV4 and intracellular calcium mediate intrinsic photosensitivity in corneal epithelial cells.
Ocul Surf
December 2024
Department of Ophthalmology & Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA; Interdepartmental Program in Neuroscience, University of Utah, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT, USA; Department of Neurobiology, University of Utah, Salt Lake City, UT, USA. Electronic address:
Purpose: To investigate intrinsic phototransduction in the corneal epithelium and its role in intracellular and inflammatory signaling.
Methods: Optical imaging in isolated corneal epithelial cells (CECs) and debrided epithelia was combined with molecular, biochemical, pharmacological assays and gene deletion studies to track UVB-induced calcium signaling and release of cytokines, chemokines and matrix remodeling enzymes. Results from wild type mouse CECs were compared to data obtained from Opn5 and Trpv4 cells.
Beyond Wolfram Syndrome 1: The Gene's Role in Alzheimer's Disease and Sleep Disorders.
Biomolecules
October 2024
Department of Human Pathology of Adulthood and Childhood G. Barresi, University of Messina, 98125 Messina, Italy.
The gene was first identified in Wolfram Syndrome 1 (WS1), a rare autosomal recessive genetic disorder characterized by severe and progressive neurodegenerative changes. 's role in various cellular mechanisms, particularly in calcium homeostasis and the modulation of endoplasmic reticulum (ER) stress, suggests its potential involvement in the pathogenesis of Alzheimer's disease (AD) and sleep disorders. Because it is involved in maintaining ER balance, calcium signaling, and stress responses, plays a multifaceted role in neuronal health.
View Article and Find Full Text PDFA non-conducting role of the Ca1.4 Ca channel drives homeostatic plasticity at the cone photoreceptor synapse.
Elife
November 2024
Department of Neuroscience, University of Texas-Austin, Austin, United States.
In congenital stationary night blindness, type 2 (CSNB2)-a disorder involving the Ca1.4 (L-type) Ca channel-visual impairment is mild considering that Ca1.4 mediates synaptic release from rod and cone photoreceptors.
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