The biotransformation of five selected pharmaceuticals ibuprofen (IBP), ketoprofen (KTP), carbamazepine (CBZ), dexamethasone (DXM) and iopromide (IOP) by a stable nitrifying enrichment culture was investigated at concentrations ranging between 25 μg/L and 2mg/L. Complete biotransformation was observed only for IBP and KTP, although, an inverse correlation between transformation rate and concentration was found. The transformation pattern observed is consistent with ammonia monooxygenase (AMO) activity. The metabolic succession of the compounds according to the biotransformation rates was: IBP>KTP>DXM>CBZ>IOP. A linear correlation between the calculated diffusive flux of the model compounds across a bilayer membrane and their biotransformation rates was found. Our results support the concept that augmentation with nitrifying activity can enhance the removal of trace organic pollutants during effluent treatment. Furthermore, ammonia-oxidizing activity appears as a good indicator for estimation of potential of biodegradability of pharmaceuticals, especially at low concentrations.
Background: Tumor recurrence or metastasis after surgery is a significant factor influencing bladder cancer (BC) prognosis. Novel molecular biomarkers are necessary to determine each patient's specific outcome because current biomarkers have limited power for predicting prognosis. The proto-oncogene MET encodes c-MET, a tyrosine kinase receptor.
Background: Increased ribosome biogenesis is required for tumor growth. In this study, we investigated the function and underlying molecular mechanism of ribosome biogenesis factor (RBIS) in the progression of non-small cell lung cancer (NSCLC).
Methods: In our study, we conducted a comprehensive analysis to identify key genes implicated in ribosome biogenesis by leveraging a Gene Set Enrichment Analysis (GSEA) dataset.
Background: Osteosarcoma (OS), the most prevalent primary malignant bone tumor in children and adolescents, arises from bone-forming mesenchymal cells. Despite advancements in surgical resection and neoadjuvant chemotherapy (cisplatin, doxorubicin, and methotrexate), chemotherapy resistance remains a significant challenge, leading to poor survival rates in patients with metastatic or recurrent OS.
Methods: In this study, we focused on the role of OTULIN, a key linear deubiquitinating enzyme, in OS chemoresistance.
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610000, Sichuan, China.
Background: Alveolar macrophages (AMs) is critical to exacerbate acute lung injury (ALI) induced by lipopolysaccharide (LPS) via inhibiting inflammation, which could by shifted by mesenchymal stem cell-derived exosomes (MSC-exos). But the underlying rationale is not fully clarified. Our study aimed to analyze the significance of itaconic acid (ITA) in mediating the protective effects of MSC-exos on LPS-induced ALI.
To efficiently remediate oil-contaminated soil, the degradation characteristics of petroleum hydrocarbons were explored using composite petroleum-degrading flora. The results showed that the degradation rates of the J0, H, HN, HK, and HKN groups were 9.82%, 33.
