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Associations between Chest Pain, Diagnosis, and Clinical Outcome in Patients Hospitalized with Acute Dyspnea: Data from the ACE 2 Study.
Cardiology
October 2024
K.G. Jebsen Center for Cardiac Biomarkers, University of Oslo, Oslo, Norway.
Introduction: Patients hospitalized due to dyspnea sometimes also report concomitant chest pain. Whether co-existing chest pain in patients with acute dyspnea associates with specific diagnosis and clinical outcome is not known.
Method: We included 313 patients admitted to Akershus University Hospital with acute dyspnea and asked the patients directly on hospital admission whether they had experienced chest pain during the last 24 h.
Multimorbidities in COPD are Associated With Increased Exacerbations and Health Care Resource Utilization in Real-World Patients from a U.S. Database.
Chronic Obstr Pulm Dis
September 2024
Novartis Pharma AG, Basel, Switzerland.
Background: Patients with chronic obstructive pulmonary disease (COPD) often develop other morbidities, suggesting a systemic component to this disease. This retrospective noninterventional cohort study investigated relationships between multimorbidities in COPD and their impact on COPD exacerbations and COPD-related health care resource utilization (HCRU) using real-world evidence from Optum's de-identified Clinformatics® Data Mart Database.
Methods: Demographic and clinical characteristics were assessed.
Symptom burden and its associations with clinical characteristics in patients with COPD: a clustering approach.
ERJ Open Res
July 2024
Department of Research and Development, Ciro, Horn, The Netherlands.
Background: Symptom burden in patients with COPD is often under-recognised. In this cross-sectional analysis, we aimed to study the severity of a variety of (non-)respiratory symptoms in patients with and without COPD and to explore the associations between clusters based on symptom severity and other clinical characteristics.
Methods: Characteristics were assessed in 538 patients with COPD from primary, secondary and tertiary care and 116 non-COPD participants.
Lung cancer among outpatients with COPD: a 7-year cohort study.
ERJ Open Res
July 2024
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Introduction: Lung cancer (LC) is the most common cause of cancer-related deaths worldwide, and its prognosis upon metastasis remains poor. Patients with COPD face a significantly elevated LC risk, up to six times greater than those with normal lung function. We aimed to investigate LC prevalence and stage distribution among COPD outpatients.
View Article and Find Full Text PDFInefficient antiviral response in reconstituted small-airway epithelium from chronic obstructive pulmonary disease patients following human parainfluenza virus type 3 infection.
Virol J
April 2024
Virology Department, AP-HP, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris, F-75010, France.
Article Synopsis
- * Human Parainfluenza Virus type 3 (HPIV-3) is frequently associated with COPD exacerbations, but its specific effects on the respiratory cells of COPD patients hadn’t been studied before this research.
- * The study found that COPD-affected respiratory cells showed heightened inflammation and a less effective antiviral response compared to healthy cells, possibly making it harder for the immune system to fight off viral infections and leading to ongoing inflammation.
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