Stem cells on alert: priming quiescent stem cells after remote injury.

Cell Stem Cell

Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Paediatrics and Molecular Genetics, University of Toronto, Toronto, ON M5R 0A3, Canada; Centre for Genetic Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

Published: July 2014

A recent paper published by Rodgers et al. describes a novel phase of stem cell quiescence, termed GAlert, that serves to prime cells in response to injury-induced signals. These stem cells are located distal to the site of injury and require mTORC1 activity to elicit the alert response.

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http://dx.doi.org/10.1016/j.stem.2014.06.012DOI Listing

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