Information on the size and shape of the neutron skin on (208)Pb is extracted from coherent pion photoproduction cross sections measured using the Crystal Ball detector together with the Glasgow tagger at the MAMI electron beam facility. On exploitation of an interpolated fit of a theoretical model to the measured cross sections, the half-height radius and diffuseness of the neutron distribution are found to be c(n)=6.70±0.03(stat.) fm and a(n)=0.55±0.01(stat.)(-0.03)(+0.02)(sys.) fm, respectively, corresponding to a neutron skin thickness Δr(np)=0.15±0.03(stat.)(-0.03)(+0.01)(sys.) fm. The results give the first successful extraction of a neutron skin thickness with an electromagnetic probe and indicate that the skin of (208)Pb has a halo character. The measurement provides valuable new constraints on both the structure of nuclei and the equation of state for neutron-rich matter.
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http://dx.doi.org/10.1103/PhysRevLett.112.242502 | DOI Listing |
Appl Radiat Isot
December 2024
Institute of Nuclear Techniques of Budapest University of Technology and Economics, Műegyetem Rkp 9, 1111, Budapest, Hungary.
This study presents a compact accelerator-driven neutron source design with a thermal neutron port and an epithermal neutron port for Boron Neutron Capture Therapy (BNCT), based on 10 mA 2.5 MeV protons bombarding on a 100 μm thick disc-shaped Li target with a diameter of 10 cm. The moderator consists of 2 parts, the epithermal neutron moderator and the thermal neutron moderator.
View Article and Find Full Text PDFBiomed Phys Eng Express
December 2024
Shandong Key Laboratory of Neutron Science and Technology, International Academy of Neutron Science, Qingdao 266199, People's Republic of China.
In this paper, we propose the design of extending collimators aimed at reducing the radiation dose received by patients with normal tissues and protecting organs at risk in Boron Neutron Capture Therapy (BNCT). Three types of extended collimators are studied: Type 1, which is a traditional design; Type 2, which is built upon Type 1 by incorporating additional polyethylene material containing lithium fluoride (PE(LiF)); Type 3, which adds lead (Pb) to Type 1. We evaluated the dose distribution characteristics of the above-extended collimators using Monte Carlo methods simulations under different configurations: in air, in a homogeneous phantom, and a humanoid phantom model.
View Article and Find Full Text PDFSci Rep
November 2024
Neuboron Therapy System Ltd, Xiamen, Fujian Province, P.R. China.
Boron Neutron Capture Therapy (BNCT) represents a revolutionary approach in targeted radiation treatment for cancer. While the therapy's potential in precise targeting is well-recognized, a critical bottleneck remains in the accurate positioning of patients for treatment delivery. This study proposes a novel automated robotic-assisted patient positioning system specifically engineered for BNCT applications.
View Article and Find Full Text PDFRadiother Oncol
January 2025
Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan; Division of Research and Development for Boron Neutron Capture Therapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045, Japan. Electronic address:
Background And Purpose: Definitive radiotherapy for patients with scalp angiosarcoma has a poor prognosis, often resulting in severe skin adverse events. Additionally, malignant melanoma is known for its radioresistant nature. Boron neutron capture therapy (BNCT) may address these challenges due to the high uptake capacity of boron drugs in these cancer types.
View Article and Find Full Text PDFBull Exp Biol Med
October 2024
Budker Institute of Nuclear Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
We studied cytotoxicity and accumulation of boron and lithium by cultured human fibroblasts and human and mouse skin melanoma cell cultures. The cytotoxicity of boron and lithium drugs was assessed by MTT tests in the boron and lithium concentration range of 10-640 μg/ml. Cell viability was significantly reduced after incubation with boron and lithium at concentrations >160 μg/ml.
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