Association of angiotensin type 2 receptor gene polymorphisms with ureteropelvic junction obstruction in Brazilian patients.

Nephrology (Carlton)

INCT/MM - National Institute of Science and Technology in Molecular Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Unity of Pediatric Nephrology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.

Published: November 2014

Aim: The angiotensin type 2 (AT2 ) receptor takes part in the process of ureteric bud during kidney development. Therefore, the gene encoding AT2 receptor, the AGTR2 gene located in the X chromosome, is a potential candidate for genetic association with Congenital Anomalies of the Kidney and Urinary Tract (CAKUT). This study aimed to investigate whether AGTR2 gene polymorphisms are associated with CAKUT in general or even with common phenotypes of CAKUT in a Brazilian sample of paediatric patients.

Methods: We analyzed 290 paediatric patients with CAKUT and 262 healthy controls from the same geographic area. TaqMan single-nucleotide polymorphism (SNP) genotyping assays for AGTR2 gene at rs1403543, rs3736556, rs35474657, rs5193 and rs5194 were performed. The sample was in Hardy-Weinberg Equilibrium for all five SNPs.

Results: The presence of CAKUT in general was not significantly associated with the SNPs included in this study. However, when patients were segregated according to major phenotypes, the diagnosis of Ureteropelvic Junction Obstruction (UPJO) was significantly associated with AGTR2 gene polymorphisms at rs3736556 and at rs5194. On the other hand, the diagnoses of vesicoureteral reflux and of multicystic dysplastic kidney were not associated with AGTR2 gene polymorphisms.

Conclusion: Our results support that the AGTR2 gene may contribute to the pathogenesis of UPJO and the genetic origin of CAKUT could vary according to phenotype expression.

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.12308DOI Listing

Publication Analysis

Top Keywords

agtr2 gene
24
gene polymorphisms
12
angiotensin type
8
gene
8
ureteropelvic junction
8
junction obstruction
8
at2 receptor
8
cakut general
8
associated agtr2
8
agtr2
6

Similar Publications

Article Synopsis
  • The study aimed to evaluate the frequency of polymorphisms in genes related to the renin-angiotensin system in COVID-19 patients and how these may correlate with the severity of the disease.* -
  • It involved 100 hospitalized patients with confirmed COVID-19, analyzing specific genetic markers related to angiotensinogen, ACE1, and angiotensin II receptors to compare their frequencies with a general population.* -
  • Results indicated a higher frequency of specific ACE1 alleles in these patients, with notable differences in the AGTR1 gene that may increase the risk of severe COVID-19, suggesting genetic factors could play a role in disease severity.*
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how different genetic variants (SNPs) in certain genes related to the renin-angiotensin system (RAS) affect the severity of COVID-19 in patients, particularly focusing on cardiovascular disease and hypertension as potential risk factors.
  • Involving 100 hospitalized COVID-19 patients, the research classified them into severe and moderate cases based on specific clinical criteria, and analyzed genetic markers using advanced PCR methods.
  • Findings indicate that specific SNPs, such as those in the ACE1 and AGTR1 genes, are linked to a higher severity of COVID-19, with significant genetic differences identified between the severe and moderate cases.
View Article and Find Full Text PDF

Rat post-mitotic septal (SEP) neurons, engineered to conditionally proliferate at 33°C, differentiate when arrested at 37.5°C and can be maintained for weeks without cytotoxic effects. Nine independent cDNA libraries were made to follow arrest-induced neural differentiation and innate immune responses in normal (Nl) uninfected and CJ agent infected SEP cells.

View Article and Find Full Text PDF

Background: The breeder rooster has played a pivotal role in poultry production by providing high-quality semen. Typically, fertility peaks between 30 and 40 weeks of age and then declines rapidly from 45 to 55 weeks of age. Research into improving fertility in aging roosters is essential to extend their productive life.

View Article and Find Full Text PDF

Icariside II in NSCLC and COVID-19: Network pharmacology and molecular docking study.

J Gene Med

July 2024

Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Background: Patients with non-small cell lung cancer (NSCLC) are susceptible to coronavirus disease-2019 (COVID-19), but current treatments are limited. Icariside II (IS), a flavonoid compound derived from the plant epimedin, showed anti-cancer,anti-inflammation and immunoregulation effects. The present study aimed to evaluate the possible effect and underlying mechanisms of IS on NSCLC patients with COVID-19 (NSCLC/COVID-19).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!