It is common for general physicians to experience diagnostic doubt and trepidation whenever faced with patients who exhibit abnormal nocturnal behaviours or excessive movements at night. There is also a perception that expensive and often poorly available overnight tests are usually required for diagnostic precision. In fact, the majority of conditions, whether they be parasomnias or, more rarely, nocturnal seizures, can be reliably diagnosed from a directed history, if available. Although the evidence base for treating parasomnias and sleep-related movement disorders remains minimal, accurate recognition is important for a variety of reasons. This review covers the diagnostic features of the full range of parasomnias and movement disorders that might present to a multidisciplinary adult sleep clinic. Throughout, it will be argued that the recognition of key or salient features obtained from a good history is the most important diagnostic tool. Indeed, when diagnostic doubt remains after a thorough sleep history, it is relatively rare for detailed tests to add much in the way of useful information.
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http://dx.doi.org/10.4997/JRCPE.2014.114 | DOI Listing |
Neuroimage Clin
January 2025
Stroke Unit, ASST Spedali Civili, «Spedali Civili» Hospital, Brescia, Italy.
The present study investigated spatial dynamic functional network connectivity (dFNC) in patients with functional hemiparesis (i.e., functional stroke mimics, FSM).
View Article and Find Full Text PDFNeurophysiol Clin
January 2025
Neuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Full Member of European Reference Network on Rare and Complex Epilepsies, EpiCARE, viale Pieraccini 24, 50139, Florence, Italy; Neurofarba Department, University of Florence, viale Pieraccini 6, 50139, Florence, Italy.
Stereo-EEG is not just a diagnostic examination but a complex methodology, requiring an accurate synthesis of many data (anatomical, clinical, neurophysiological, cognitive, metabolic, and genetic). The implantation scheme is decided based on a hypothesis (or hypotheses) of epileptogenic zone localization. Subsequently, intracerebral electrical stimulation is used to define the extent of highly functional cortical regions and to reproduce the clinical symptoms and signs associated with seizures.
View Article and Find Full Text PDFUnlabelled: The basal ganglia play a crucial role in action selection by facilitating desired movements and suppressing unwanted ones. The substantia nigra pars reticulata (SNr), a key output nucleus, facilitates movement through disinhibition of the superior colliculus (SC). However, its role in action suppression, particularly in primates, remains less clear.
View Article and Find Full Text PDFJ Neurol Phys Ther
January 2025
Center of Expertise for Parkinson & Movement Disorders, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Gelderland, the Netherlands (S.S., N.M.V., S.K.L.D., B.R.B.); Harvard Medical School, Boston, Massachusetts (A.A., M.A.S., E.A.M.); Departments of Epidemiology and Nutrition, T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts (A.A.); Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts (M.A.S., E.A.M.); Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts (M.A.S.); and Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts (E.A.M.).
Background And Purpose: Physical activity has beneficial symptomatic effects for people with Parkinson's disease (PD), but increasing-and sustaining-a physically active lifestyle remains challenging. We investigated the feasibility (ability to increase step counts) and usability of a behavioral intervention using a motivational smartphone application to remotely increase physical activity in PD.
Methods: We performed a 4-week, double-blind pilot trial.
Nutr Metab (Lond)
January 2025
Department of Sports Medicine, China Medical University, Taichung City, Taiwan.
Background: Intermittent fasting (IF) can be an effective dietary therapy for weight loss and improving cardiometabolic health. However, there is scant evidence regarding the role of IF on indicators of liver function, particularly in adults with metabolic disorders. Therefore, we performed a systematic review and meta-analysis to investigate the effects of IF on liver function in adults with metabolic disorders.
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