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| http://dx.doi.org/10.1007/s00270-014-0945-7 | DOI Listing |
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The Combined Delivery of the , , and Genes Stimulates Angiogenesis and Improves Post-Ischemic Innervation and Regeneration in Skeletal Muscle.
Curr Issues Mol Biol
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Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia.
In this study, the effects of different combinations of the genes , , and injected both using direct virus-mediated injection (adenovirus, Ad5) and umbilical cord blood mononuclear cells (UCBCs) on the processes of stimulation of post-ischemic innervation, angiogenesis, and regeneration in skeletal muscle were investigated in a rat hindlimb chronic ischemia model. It was shown that more pronounced stimulation of angiogenesis and restoration of post-ischemic innervation were achieved both in the early (28 days post-ischemia, dpi) and late (42 dpi) terms of the experiment in the calf muscle when UCBCs delivered the combination of Ad5- and Ad5- compared to the direct injection of the same vector combination into the area of ischemia. At the same time, the inclusion of Ad5- in the combination of Ad5- and Ad5- directly injected or administered by UCBCs provided a significant increase in the number of centronuclear muscle fibers, indicating stimulation of post-ischemic reparative myogenesis.
View Article and Find Full Text PDF3D impression to facilitate in situ surgical renal segmental artery aneurysm repair: A novel open approach option for an unusual vascular condition.
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Department of Anesthesiology, Edgardo Rebagliati Martins National Hospital, Lima, Peru.
Objectives: Renal Artery Aneurysms (RAA) affect approximately 0.01%-0.97% of the population.
View Article and Find Full Text PDF[Management of Stent-graft migration with obstruction of supra-aortic vessel during an endovascular procedure for aortic isthmus rupture].
Ann Cardiol Angeiol (Paris)
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Service de chirurgie cardiaque, Centre hospitalier universitaire Grenoble Alpes, La Tronche, France. Electronic address:
The endovascular approach is widely used in the management of aortic isthmic rupture. Even if it remains less invasive than conventional surgery, a life-threatening complications are possible. We report the case of a young female patient presenting a stent-graft migration during the deployment with total obstruction of the supra-aortic vessels.
View Article and Find Full Text PDFCellular therapies in no-option critical limb ischemia: present status and future directions.
Postepy Kardiol Interwencyjnej
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Department of Vascular Surgery and Endovascular Interventions, John Paul II Hospital, Krakow, Poland.
Critical limb ischemia - an advanced stage of lower extremity arterial disease with presence of rest pain and/or ischemic ulcers - remains an important cause of major amputations and disability in developed societies. Novel treatment strategies are urgently needed to prevent (or delay) amputations in particular for patients in whom effective revascularization is no longer feasible for anatomic and/or technical reasons (no-option critical limb ischemia - N-O CLI). Cellular therapies have been gaining the growing attention of researchers and clinicians in the last two decades.
View Article and Find Full Text PDFKinking of Frozen Elephant Trunk Hybrid Prostheses: Incidence, Mechanism, and Management.
Front Cardiovasc Med
April 2022
Vascular & Endovascular Surgery, Velindre University NHS Trust, Health Education & Improvement Wales (HEIW), Cardiff, United Kingdom.
Introduction: Kinking of the Frozen Elephant Trunk (FET) stent graft is one of the most devastating complications of the FET procedure. It can present post-operatively with reduced arterial pressures in the lower limbs and intermittent claudication. However, it can also be visualized intra-operatively by the surgeons.
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