Testing hypotheses on a respondent's individual fit under the Rasch model requires knowledge of the distributional properties of a person fit statistic. We argue that the Rasch Sampler (Verhelst, 2008), a Markov chain Monte Carlo algorithm for sampling binary data matrices from a uniform distribution, can be applied for simulating the distribution of person fit statistics with the Rasch model in the same way as it used to test for other forms of misfit. Results from two simulation studies are presented which compare the approach to the original person fit statistics based on normalization formulas. Simulation 1 shows the new approach to hold the expected Type I error rates while the normalized statistics deviate from the nominal alpha-level. In Simulation 2 the power of the new approach was found to be approximately the same or higher than for the normalized statistics under most conditions.
Background: Traditional cognitive assessments, often reliant on paper-and-pencil tests and professional evaluators, suffer from subjectivity and limited result discrimination. This study introduces the Baguan Online Cognitive Assessment System (BOCAS), a tablet-based system that evaluates both general cognitive ability (GCA) and domain-specific functions across six domains: sensory-motor skills, processing speed, sustained attention, working memory, cognitive flexibility, and spatial ability.
Methods: BOCAS was validated with 151 healthy Chinese adults aged 18-40.
Laboratory Medicine Center, Department of Genetic and Genomic Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Background: GTPBP3 catalyzes τm(s) U biosynthesis at the 34th wobble position of mitochondrial tRNAs, the hypomodification of τmU leads to mitochondrial disease. While twenty-three variants of GTPBP3 have been reported worldwide, the genetic landscape in China remains uncertain.
Methods: By using whole-exome sequencing, the candidate individuals carrying GTPBP3 variants were screened and identified.
Background: Adverse effects during chemotherapy severely impact the daily diet of breast cancer (BC) patients. Engaging in dietary self-management is crucial for healthy lifestyle and recovery. This study aims to create the Dietary Self-management Behavior Questionnaire (DSMBQ) and preliminarily validate its reliability, validity, and discriminative ability for BC patients undergoing chemotherapy.
Department of Epidemiology and Health Statistics/West China Fourth Hospital and West China School of Public Health, Sichuan University, Chengdu 610041, China.
Objective: Exploring factors influencing the continued use intention of health science popularization WeChat accounts among university students in Chengdu.
Methods: Stratified cluster random sampling was employed to select students from 10 universities in Chengdu in 2023 as research subjects, with data collected via a questionnaire. The questionnaire encompassed demographic information, usage patterns of health science popularization WeChat accounts, and factors influencing continued use intentions.
Epilepsy, a prevalent neurological disorder characterized by spontaneous recurrent seizures, significantly impacts physiological and cognitive functions. Emerging evidence suggests a crucial role for metabolic factors, particularly lactate, in epilepsy. We discuss the applicability of the Astrocyte-Neuron Lactate Shuttle (ANLS) model during acute seizure events and examine lactate's metabolic adaptation in epilepsy progression.
