The new diimine fluorescent ligand ACRI-1 based on a central acridine yellow core is reported along with its coordination complex [Co2 (ACRI-1)2 ] (1), a fluorescent weak ferromagnet. Due to the strong fluorescence of the acridine yellow fluorophore, it is not completely quenched when the ligand is coordinated to Co(II) . The magnetic properties of bulk complex 1 and its stability in solution have been studied. Complex 1 has been deposited on highly ordered pyrolitic graphite (HOGP) from solution. The thin films prepared have been characterized by AFM, time-of-flight secondary ion mass spectrometry (TOF-SIMS), grazing incidence X-ray diffraction (GIXRD), X-ray absorption spectroscopy (XAS), X-ray magnetic circular dichroism (XMCD) and theoretical calculations. The data show that the complex is robust and remains intact on the surface of graphite.
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http://dx.doi.org/10.1002/chem.201402814 | DOI Listing |
Sci Rep
December 2024
Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, AZ, USA.
Idiopathic pulmonary fibrosis (IPF) is a fatal disease defined by a progressive decline in lung function due to scarring and accumulation of extracellular matrix (ECM) proteins. The SOCS (Suppressor Of Cytokine Signaling) domain is a 40 amino acid conserved domain known to form a functional ubiquitin ligase complex targeting the Von Hippel Lindau (VHL) protein for proteasomal degradation. Here we show that the SOCS conserved domain operates as a molecular tool, to disrupt collagen and fibronectin fibrils in the ECM associated with fibrotic lung myofibroblasts.
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December 2024
State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, PR China.
The INO80 chromatin remodeling complex plays a critical role in shaping the dynamic chromatin environment. The diverse functions of the evolutionarily conserved INO80 complex have been widely reported. However, the role of INO80 in modulating the histone variant H2A.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Physics and Astronomy, University of Calgary, 2500 University Drive N.W., Calgary, T2N 1N4, AB, Canada.
Patterns of ionospheric luminosity provide a unique window into our complex, coupled space environment. The aurora, for example, indicates plasma processes occurring thousands of km away, depositing immense amounts of energy into our polar ionospheres. Here we show observations of structured continuum emission associated with the dynamic aurora.
View Article and Find Full Text PDFBrain Res
December 2024
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Shandong First Medical University (The Shandong Province Qianfoshan Hospital), Jinan 250014, PR China. Electronic address:
Background: Maintaining autophagic homeostasis has been proved to play an important role in Alzheimer's disease.
Object: The aim of this study was to investigate the effect of Fuzhisan(FZS) on autophagic function in Alzheimer's disease and to elucidate its potential mechanism through the P62 regulatory pathways.
Methods: FZS was extracted by water extraction-rotary evaporation method.
Int J Pharm
December 2024
SkinAxis LLC, Cedar Knolls, NJ, USA. Electronic address:
In this study we evaluated the effects of flow lamination on aerosol flow dynamics and deposition at the exit point in testing models with spatial barriers (narrowing or curving).We compared ModiFlow (MF) to an idealized Standard Spacer (SS) in their efficiency of delivery of aerosolized medication (fluticasone) across different types of spatial barriers. Fluticasone propionate HFA Inhaler from Prasco Labs 220 µg per actuation was used to deliver 1 spray in each test tube.
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