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When and how are complications suspected after shunt surgery in patients with normal pressure hydrocephalus?
Acta Neurochir (Wien)
January 2025
Department of Medical Sciences, Neurosurgery, Uppsala University, Uppsala, Sweden.
Purpose: The follow-up routine for patients with idiopathic normal pressure hydrocephalus (iNPH) after shunt surgery differs across medical centers. Shunt surgery is not without risks, with complications emerging at various times after the procedure. The aim was to explore the timing and methods of detecting complications following ventriculoperitoneal shunt surgery for iNPH.
View Article and Find Full Text PDFEndoplasmic reticulum stress causes long bone shortening in P4hb mice: A mouse model exhibiting significant features of cole-carpenter syndrome driven by P4HB mutations.
Biochim Biophys Acta Mol Basis Dis
January 2025
Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Cole-Carpenter syndrome (CCS) is a rare autosomal-dominant genetic disease characterized by craniosynostosis, ocular proptosis, hydrocephalus, distinctive facial features, and bone fragility. Previous cases of CCS are associated with genetic variations in P4HB, which encodes the protein disulfide isomerase (PDI), a key enzyme in protein folding. Patients with CCS caused by P4HB mutations often present with short stature, limb deformities, and abnormal epiphyseal plates.
View Article and Find Full Text PDFShunt-Dependent Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage: Investigation of Prognostic Variables and Creation of a Stronger Predictive Model.
World Neurosurg
January 2025
Department of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road NE, Ste. B6200, Atlanta, Georgia, USA 30322; Radiology and Imaging Sciences, Division of Interventional Neuroradiology, Emory University School of Medicine, 1364 Clifton Road NE, AG26, Atlanta, Georgia, USA, 30322.
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is frequently complicated by permanent shunt-dependent hydrocephalus, but it is difficult to predict which patients are at highest risk.
Objective: This study seeks to identify novel variables associated with shunt dependency after aSAH and to create a predictive algorithm that improves upon existing models.
Methods: Retrospective case control design was used.
A Rare Case of Concurrent Intraventricular Meningioma and Choroid Plexus Papilloma: A Case Report.
Medicina (Kaunas)
December 2024
Department of General and Clinical Pathology, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
This case presents an unusual combination between an intraventricular meningioma and a choroid plexus papilloma. Intraventricular meningiomas are rare intraventricular tumors presenting with symptoms of hydrocephalus, headache, and neurological deficits. The rarity of choroid plexus papillomas is highlighted in medical diagnostics, with the majority of these findings being incidental within the setting of obstructive hydrocephalus.
View Article and Find Full Text PDFThe Role of Transcranial Ultrasound Imaging in Intensive Care Treatment of Decompressive Hemicraniectomy Patients: A Retrospective Single-Center Analysis.
J Clin Med
December 2024
Department of Neurosurgery, Bezirkskrankenhaus Günzburg, University of Ulm, Lindenallee 2, 89312 Günzburg, Germany.
: Post-hemicraniectomy patients often need extended intensive care treatment. While computed tomography (CT) is considered the gold standard for regular imaging, its frequent use could be linked to adverse clinical outcomes. This study aimed to assess bedside transcranial ultrasound (TUS) to capture intracranial anatomical structures and pathologies.
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