Despite the ubiquitous use of the flexed arm hang (FAH) as a field test of muscular fitness, evidence for the construct validity of it is lacking. The strongest validity coefficients (r) to date are 0.71 and 0.72 found by correlating modified versions of the FAH (i.e., 90 and 180° of elbow extension, respectively) with relative dynamic strength (i.e., 1 repetition maximum [1RM] lat pull downs × body mass). Considering a significant portion of all FAH and modified flexed arm hang (MFAH) performances are isometric, the test may be more correlated with the construct of relative isometric strength (RIS) rather than relative dynamic strength. The purpose of this study was to determine if the construct validity of the 90° MFAH might be strengthened by correlating it with either absolute isometric strength (AIS) (i.e., maximum volitional isometric contraction [MVIC]) or RIS (i.e., MVIC × body mass). Thirty-one college-aged women participated in the study. Inter-rater reliability coefficients for two 90° MFAH tests were determined using intraclass correlation coefficient (ICC): F1,30 = 1.356, ICC = 0.99; F1,30 = 0.675, ICC = 0.99. In addition, test-retest reliability was also found to be excellent: F1,30 = 3.809; ICC = 0.98. Pearson product moment correlation (r) was used at an adjusted alpha level of 0.025 to examine construct validity of the 90° MFAH with both AIS (MVIC) and RIS (MVIC × body mass). Results indicated no significant relationship with AIS (r = 0.096, p = 0.606); however, a strong significant relationship emerged with RIS (r = 0.878, p = 0.000). It was concluded that 90° MFAH scores alone were not related to absolute strength; however, they were found to be a valid and reliable estimate of the construct of RIS.
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http://dx.doi.org/10.1519/JSC.0000000000000601 | DOI Listing |
ACS Nano
January 2025
Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong 999077, China.
Real-time monitoring of hemodynamics is crucial for diagnosing disorders within implanted vascular grafts and facilitating timely treatment. Integrating vascular grafts with advanced flexible electronics offers a promising approach to developing smart vascular grafts (SVGs) capable of continuous hemodynamic monitoring. However, most existing SVG devices encounter significant challenges in practical applications, particularly regarding biomechanical compatibility and the effective evaluation of vascular status.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Dermatology, the Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guilin, China. Electronic address:
Many atopic dermatitis (AD) patients have suboptimal responses to Dupilumab therapy. This study identified key genes linked to this resistance using multi-omics approaches to benefit more patients. We selected a prospective cohort of 54 CE treated with Dupilumab from the GEO database.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
January 2025
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China; Beijing Institute of Traditional Chinese Medicine, Beijing, China. Electronic address:
Vitiligo is a common chronic skin depigmentation disorder that seriously decreases the patients' overall quality of life. Human blood metabolites could contribute to unraveling the underlying biological mechanisms of vitiligo. We used GWAS summary statistics to assess the causal association between genetically predicted 1,400 serum metabolites and vitiligo risk by Mendelian randomization (MR).
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200433, China. Electronic address:
Objective: Gliomas pose a significant global health challenge due to high rates of morbidity and mortality. Recent research has indicated that circular RNAs (circRNAs) may play a crucial role in gliomas. However, the specific impacts of circRNAs on gliomas development is poorly understood.
View Article and Find Full Text PDFCurr Res Transl Med
January 2025
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Background: Stromal cells play a pivotal role in the tumor microenvironment (TME), significantly impacting the progression of acute myeloid leukemia (AML). This study sought to develop a stromal-related prognostic model for AML, aiming to uncover novel prognostic markers and therapeutic targets.
Methods: RNA expression data and clinical profiles of AML patients were retrieved from the Cancer Genome Atlas (TCGA).
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