Objective: The objectives of this study were to determine the clinical success of colorectal stenting in patients with large bowel obstruction secondary to gynaecologic malignancy and to determine whether there are any predictors of outcome.
Methods: This was a retrospective cohort study of all patients with a gynaecologic malignancy and large bowel obstruction referred for colorectal stenting at Vancouver General Hospital between January 2006 and February 2013. All stents were placed using image guidance with the exception of one placed endoscopically. Information was extracted from the medical record. Data were analysed using descriptive statistics. Chi-square and Fisher's exact tests were used to compare stent outcomes and clinical variables.
Results: There were 32 patients in the study. The median age was 66 (range 40-78). The median follow-up was 28.9 months (range 0.8-481). The primary tumour was ovarian in 75% and uterine in 18.8%. Seventy-five percent of patients had a technically successful stent insertion. Of these, 37.5% had a complication requiring intervention. The rate of clinical success was 47%. There were no statistically significant associations between any clinical variables and failed stent insertion or complications.
Conclusion: Colorectal stenting in patients with a large bowel obstruction secondary to gynaecologic malignancy is associated with a high rate of technical success but a low rate of clinical success. There were no clinical predictors of outcome identified in this study. If patients are offered this procedure, they should be counselled about the anticipated benefit and associated risks.
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http://dx.doi.org/10.1016/j.ygyno.2014.06.020 | DOI Listing |
Gynecol Oncol Rep
February 2025
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, USA.
Background: Endometriosis is a common condition with a rare malignant potential. We report a case of a patient with a colon mass who underwent surgery for malignant endometriosis associated cancer.Case: A 70-year-old woman with a pelvic mass who was lost to follow-up for 6 years represented with an enlarging pelvic mass involving the sigmoid colon.
View Article and Find Full Text PDFFront Immunol
January 2025
The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Background: Cervical cancer is the fourth most common cancer in women globally, and the main cause of the disease has been found to be ongoing HPV infection. Cervical cancer remains the primary cause of cancer-related death despite major improvements in screening and treatment approaches, especially in low- and middle-income nations. Therefore, it is crucial to investigate the tumor microenvironment in advanced cervical cancer in order to identify possible treatment targets.
View Article and Find Full Text PDFFront Cell Dev Biol
January 2025
Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University, Frankfurt, Germany.
The protein regulator of cytokinesis 1 (PRC1) is a key regulator of microtubule crosslinking and bundling, which is crucial for spindle formation and cytokinesis. RITA, the BP-J nteracting and ubulin-ssociated protein, is a microtubule associated protein. We have reported that RITA localizes to mitotic spindles modulating microtubule dynamics and stability as well as to spindle poles affecting the activity of Aurora A.
View Article and Find Full Text PDFJ Obstet Gynaecol Res
January 2025
Reproductive Sciences and Technology Research Center, Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Objective: To evaluate the efficacy of a microfluidic culture system supplemented with follicular fluid meiosis-activating sterol (FF-MAS) on the maturation of immature oocytes in patients with polycystic ovarian syndrome (PCOS).
Methods: A total of 438 germinal vesicle oocytes from 163 PCOS patients were included. Oocytes were divided into five groups: (1) cultured in static drops without FF-MAS, (2) cultured in static drops with FF-MAS, (3) cultured in a microfluidic device without FF-MAS, (4) cultured in a microfluidic device with FF-MAS for the first 2 h, and (5) cultured in a microfluidic device with FF-MAS for 24 h.
Hu Li Za Zhi
February 2025
Department of Nurse-Midwifery and Women Health, National Taipei University of Nursing and Health Sciences, Taiwan, ROC.
Background: Pap smear screenings effectively reduce the incidence of cervical cancer. However, the effectiveness of practical teaching strategies for this procedure is seldom discussed.
Purpose: This study was designed to evaluate the effectiveness of a Pap smear screening training approach using the two strategies of classroom simulation and practical community screening demonstrations.
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