Physiology-based pharmacokinetic (PBPK) modeling is well recognized as a technology for mechanistically simulating and predicting the fate of substances in a mammalian body. Today, the demand for this methodology is higher than ever. The pharma industry and regulatory agencies are looking for new methods, which help to speed up and increase the efficiency of the development process for new drugs. Implementing PBPK modeling in the drug research and development workflow contributes significantly to reach this goal.:
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| http://dx.doi.org/10.1016/j.ddtec.2005.01.001 | DOI Listing |
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