We demonstrate a simple but efficient design for forming tunable single, double and triple quantum dots (QDs) in a sub-μm-long carbon nanotube (CNT) with two major features that distinguish this design from that of traditional CNT QDs: the use of i) Al2Ox tunnelling barriers between the CNT and metal contacts and ii) local side gates for controlling both the height of the potential barrier and the electron-confining potential profile to define multiple QDs. In a serial triple QD, in particular, we find that a stable molecular coupling state exists between two distant outer QDs. This state manifests in anti-crossing charging lines that correspond to electron and hole triple points for the outer QDs. The observed results are also reproduced in calculations based on a capacitive interaction model with reasonable configurations of electrons in the QDs. Our design using artificial tunnel contacts and local side gates provides a simple means of creating multiple QDs in CNTs for future quantum-engineering applications.
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http://dx.doi.org/10.1088/0957-4484/25/29/295201 | DOI Listing |
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2024
Department of Biomedical Engineering, Ankara University, Ankara, Turkey.
Objective: The production of 3-dimensional models and materials according to preoperative virtual surgical planning is a time-consuming process and causes high costs. We aimed to demonstrate the navigation mediated reconstruction of the patients who underwent the removal of a tumoral mass in midfacial region according to their preoperatively prepared surgical plannings.
Study Design: Patients who underwent the removal of tumoral mass and reconstruction in their midfacial region were included in the study.
J Control Release
December 2024
Jiangsu Key Laboratory of Neuropsychiatric Diseases Research, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development, Soochow University, Suzhou 215123, China. Electronic address:
Many brain-targeting drug delivery strategies have been reported to permeate the blood-brain barrier (BBB) via hijacking receptor-mediated transport. However, these receptor-based strategies could mediate whole-brain BBB crossing due to the wide intracranial expression of target receptors and lead to unwanted accumulation and side effects on healthy brain tissues. Inspired by brain metastatic processes and the selectivity of brain metastatic cancer cells for the inflammatory BBB, a biomimetic nanoparticle was developed by coating drug-loaded core with the inflammatory BBB-seeking erythrocyte-brain metastatic hybrid membrane, which can resist homotypic aggregation and specially bind and permeate the inflammatory BBB for specific drug delivery.
View Article and Find Full Text PDFPhytomedicine
December 2024
Jinan Central Hospital, Shandong First Medical University, Jinan 250013, Shandong, China. Electronic address:
Background: The dysregulation of ribosome biogenesis has been extensively identified in various cancers, making it emerge as a hallmark of malignant cells. This highlights the potential of targeting ribosome biogenesis as an effective approach for treating cancer patients. Although chemotherapy drugs including doxorubicin and cisplatin often target ribosome biogenesis to induce DNA damage or inhibit tumor cell proliferation, they are associated with significant side effects.
View Article and Find Full Text PDFBMC Surg
December 2024
AJA Universty of Medical Sciences, Tehran, Iran.
Background: Optimal selection of anastomosis technique is crucial in colectomy surgeries to ensure success and minimize postoperative complications. Various methods, both manual and stapler-assisted, are employed for intestinal anastomosis. This study aims to compare two surgical methods of intestinal anastomosis through macroscopic and microscopic examination.
View Article and Find Full Text PDFNeurol Sci
December 2024
Neurology Unit, Department of Neurosciences, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Background: Drug-resistant epilepsy (DRE) secondary to hypothalamic hamartoma (HH) often requires surgical resection or stereotactic radiosurgery, which frequently fail to provide satisfactory outcomes and are associated with severe side effects. Magnetic resonance-guided focused ultrasound (MRgFUS) may represent a minimally invasive surgical approach to HH by offering precise thermal ablation of sub-millimetric brain targets while sparing surrounding structures.
Methods: We present the case of a 19-year-old man with HH-associated DRE, who was successfully treated with MRgFUS.
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