Tissue microarrays for early target evaluation.

Drug Discov Today Technol

Division of Molecular Pathology, Institute of Pathology, Basel University Hospital, Schoenbeinstrasse 40, CH-4031 Basel, Switzerland. Electronic

Published: September 2004

Early assessment of the probable biological importance of drug targets, the potential market size of a successful new drug, and possible treatment side effects are critical for risk management in drug development. A comprehensive molecular epidemiology analysis involving thousands of well-characterized human tissues will thus provide vital information for strategic decision-making. Tissue microarray (TMA) technology is ideally suited for such projects. The simultaneous analysis of thousands of tissues enables highly standardized, fast and affordable translational research studies of unprecedented scale.:

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http://dx.doi.org/10.1016/j.ddtec.2004.08.003DOI Listing

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