AI Article Synopsis
- A new highly reactive alkylrhodium complex was created from Me(2)Zn and RhCl(PPh(3))(3), which successfully catalyzed a Csp(3)-Csp(3) homocoupling reaction of benzyl halides.
- This type of Csp(3)-Csp(3) coupling reaction using a Rh catalyst has not been documented before.
- The reaction occurred under mild conditions and produced the desired homocoupling products, even when reactive groups like formyl or hydroxymethyl were present.
Article Abstract
A highly reactive alkylrhodium complex was formed from Me(2)Zn and RhCl(PPh(3))(3) and effectively catalyzed a Csp(3)-Csp(3) homocoupling reaction of benzyl halides. A Csp(3)-Csp(3) coupling reaction using Rh catalyst has not been reported up to now. The reaction proceeded under very mild conditions and gave the corresponding homocoupling products even if they had reactive substituents such as an uncovered formyl or hydroxymethyl group.
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| http://dx.doi.org/10.1021/ol501619w | DOI Listing |
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