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ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states.
iScience
November 2024
Molecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052 Ghent, Belgium.
About 5% of patients with cutaneous squamous cell carcinoma (cSCC) have a poor prognosis which is associated with a loss of tumor differentiation, invasion and metastasis, all of which are linked to the process of epithelial-to-mesenchymal plasticity (EMP). Here, we showed that the EMP-associated transcription factor ZEB2 drives cSCC heterogeneity which resembles biphasic carcinosarcoma-like tumors. Single cell RNA sequencing revealed distinct subpopulations ranging from fully epithelial (E) to intermediate (EM) to fully mesenchymal (M), associated with the gradual loss of cell surface markers EPCAM, CDH1, ITGB4, and CD200.
View Article and Find Full Text PDFStudy on the expression and prognostic relationship of in liver cancer based on bioinformatics.
World J Clin Oncol
September 2024
Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China.
Article Synopsis
- Primary liver cancer is a major health issue with a poor prognosis and high recurrence rates, making early detection vital yet difficult.
- Myosin proteins, especially a specific myosin light chain, are key in the development of cancer and may serve as biomarkers for prognosis, particularly in liver hepatocellular carcinoma (LIHC).
- The study found that this myosin light chain is highly expressed in LIHC and correlates with worse overall and disease-free survival, indicating its potential as a target for further research and treatment strategies.
Malignant Proliferating Pilar Tumor With Sarcomatous Transformation ("Carcinosarcoma"): Case Report With Molecular Profile.
Am J Dermatopathol
January 2025
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Article Synopsis
- Malignant proliferating pilar tumors (MPPTs) are uncommon skin tumors, and cases with sarcomatous transformation are even rarer, with only four documented prior instances.
- This report details a unique case of MPPT with sarcomatous transformation in a 63-year-old male, incorporating molecular, histological, and immunohistochemical analyses alongside follow-up information.
- Genetic findings revealed specific mutations, including a loss-of-function TP53 mutation in both tumor components and an inactivating CDKN2A mutation specific to the sarcomatous part, with the patient remaining disease-free for two years post-diagnosis.
The Rarity in the Rarity: Presentation of Three Cases of Cutaneous Carcinosarcoma with Clinical and Histopathological Insights.
Dermatopathology (Basel)
July 2024
Dermatology Clinic, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Article Synopsis
- * The exact cause of cCS is unknown; it may arise from a single cell capable of differentiating into both types of tissue or from the interaction of existing carcinoma and sarcoma cells.
- * Histologically, cCS can show various types of epithelial and sarcomatous characteristics, necessitating further research to improve understanding of its development and treatment options.
Cutaneous metastasis of uterine carcinosarcoma mimicking drug eruption.
JAAD Case Rep
May 2024
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
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