Regulatory T cells and cancer: an undesired tolerance.

Kidney Int

1] Unité Mixte de Recherche INSERM 1098, Fédération Hospitalo-Universitaire INCREASE, Besançon, France [2] Université de Franche-Comté Institut Fédératif de Recherche 133, Besançon, France [3] Centre Hospitalier Universitaire, Besançon, France [4] Centre d'Investigation Clinique en Biothérapies 506, Besançon, France.

Published: July 2014

The incidence of cancer is markedly increased in organ transplant patients. A better understanding of underlying mechanisms and the identification of biomarkers for diagnosis and prognosis are major challenges. Hope et al. report expansion of regulatory T cells to be associated with the presence and severity of cancer. Although relevant, these results raise several questions.

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Source
http://dx.doi.org/10.1038/ki.2014.46DOI Listing

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