Eriksen et al. unmask an independent link between a high glomerular filtration rate (GFR) and subclinical cardiovascular damage in a large cohort of nondiabetic middle-aged people in Tromsø, Norway. Although others have previously reported an association between estimated GFR and cardiovascular risk factors, the present work is remarkable in that it relies on measured GFR, thus overcoming potential bias of the limited accuracy of common GFR estimates in individuals with high GFR values.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ki.2013.545 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Population pharmacokinetics and dosing simulations of temocillin in liver transplanted paediatric patients: a prospective, open-label, non-randomized study.
Clin Microbiol Infect
December 2024
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address:
Objectives: Temocillin is a β-lactam antibiotic used for preventing or treating bacterial infections in liver-transplanted children. We characterized its pharmacokinetics in plasma and ascitic fluid and proposed dosing regimens that maximize achievement of effective drug exposures in this patient group.
Methods: Patients aged 6-36 months received 25 mg/kg/12h (n=14) or 25 mg/kg/8h (n=23).
Resazurin dye is an in vivo sensor of kidney tubular function.
Kidney Int
December 2024
Division of Pharmaceutics and Pharmacology, College of Pharmacy & Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA. Electronic address:
Glomerular filtration rate (GFR) is the main functional index of kidney health and disease. Currently, no methods are available to directly measure tubular mass and function. Here, we report a serendipitous finding that the in vitro cell viability dye resazurin can be used in mice as an exogenous sensor of tubular function.
View Article and Find Full Text PDFApproach to investigation and management of proteinuria in pregnancy.
Clin Med (Lond)
December 2024
Women's Centre, John Radcliffe Hospital, Oxford University Hospitals, Headley Way, Headington, OX3 9DU. Electronic address:
Pregnancy leads to significant changes in renal physiology which results in increased in glomerular filtration rate (GFR) and enhanced protein excretion. These changes may continue in the postnatal period and might be observed for five to six months after birth. Once confirmed, proteinuria warrants investigation and close surveillance.
View Article and Find Full Text PDFChronic kidney disease (CKD) is a common clinical condition with significant health risks for patients and is widely recognised as a major public health concern. Laboratory medicine plays a crucial role in both diagnosing and managing CKD, as diagnosis and staging rely on estimated glomerular filtration rate (GFR) and evaluating albuminuria (or proteinuria). It was evident that the laboratory assessment of CKD in Malaysia is not standardised.
View Article and Find Full Text PDFDapagliflozin in acute heart failure management: a systematic review and meta-analysis of safety and effectiveness.
BMC Cardiovasc Disord
December 2024
Department of Internal Medicine, AdventHealth Sebring, Sebring, FL, USA.
Background: Acute Heart Failure (AHF) presents as a serious pathophysiological disease with significant morbidity and mortality rates, requiring immediate medical intervention. Traditional treatment involves diuretics and vasodilators, but a subset of patients develop resistance due to acute cardiorenal syndrome. Dapagliflozin, categorized as a sodium-glucose cotransporter-2 inhibitor (SGLT2i), has emerged as a promising therapy for AHF, demonstrating substantial benefits in reducing both mortality and morbidity among patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!