Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057074 | PMC |
| http://dx.doi.org/10.1186/cc13806 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Schlemm's canal-selective Tie2/TEK knockdown induces sustained ocular hypertension in adult mice.
Exp Eye Res
November 2024
Department of Neurobiology, University of Utah, Salt Lake City, UT, 84132, USA. Electronic address:
Deficient Angiopoietin-Tie2 signaling is linked to ocular hypertension in glaucoma. Receptor Tie2/TEK expression and signaling at Schlemm's canal (SC) is indispensable for canal integrity and homeostatic regulation of aqueous humor outflow (AHO) and intraocular pressure (IOP), as validated by conditional deletion of Tie2, its ligands (Angpt1, Angpt2 and Angpt3/4) or regulators (Tie1 and PTPRB/VE-PTP). However, these Tie2/TEK knockouts and conditional knockouts are global or endothelial, preventing separation of systemic and ocular vascular defects that impact retinal or renal integrity.
View Article and Find Full Text PDFModulation of angiopoietin-2 and Tie2: Organ specific effects of microvascular leakage and edema in mice.
Microvasc Res
July 2024
Department of Anesthesiology, Amsterdam UMC, VU University, Amsterdam, the Netherlands; Department of Intensive Care Medicine, Amsterdam UMC, University of Amsterdam, the Netherlands; Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC, University of Amsterdam, the Netherlands. Electronic address:
Introduction: Critical illness is associated with organ failure, in which endothelial hyperpermeability and tissue edema play a major role. The endothelial angiopoietin/Tie2 system, a regulator of endothelial permeability, is dysbalanced during critical illness. Elevated circulating angiopoietin-2 and decreased Tie2 receptor levels are reported, but it remains unclear whether they cause edema independent of other critical illness-associated alterations.
View Article and Find Full Text PDFFemale sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.
PLoS One
November 2023
Department of Anesthesiology, Amsterdam UMC, VU University, Amsterdam, The Netherlands.
Background: The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investigated whether there are sex-related differences in the endothelial angiopoietin/Tie2 system and edema formation.
View Article and Find Full Text PDFActivation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways.
J Am Soc Nephrol
June 2023
Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Significance Statement: Ischemia-reperfusion AKI (IR-AKI) is common and causes significant morbidity. Effective treatments are lacking. However, preclinical studies suggest that inhibition of angiopoietin-Tie2 vascular signaling promotes injury, whereas activation of Tie2 is protective.
View Article and Find Full Text PDFEndothelial Tyrosine Kinase Tie1 Is Required for Normal Schlemm's Canal Development-Brief Report.
Arterioscler Thromb Vasc Biol
March 2022
Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago. Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago.
Background: Schlemm's canal (SC) is a large vessel residing in the iridocorneal angle and is required to regulate aqueous humor outflow. Normal SC structure and function is indispensable for maintaining normal intraocular pressure, and elevated intraocular pressure is a risk factor for development of glaucoma. Recent reports have identified a key role of the angiopoietin-Tie2 pathway for SC development and function; however, the role of the orphan receptor Tie1 has not been clarified.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!