AI Article Synopsis
- Antiosteoporotic agents currently studied for their impact on glucose and lipid metabolism include bisphosphonates, SERMs, and activated vitamin D.
- Bisphosphonates are linked to potential improvements in glucose metabolism but have minimal effects on lipid levels, while SERMs decrease triglycerides and LDL cholesterol and increase HDL cholesterol, with no evidence yet of reducing coronary event risks.
- Vitamin D may enhance lipid and glucose metabolism, but its effectiveness in treating lifestyle-related diseases remains unclear.
Article Abstract
At present, antiosteoporotic agents that might affect glucose and/or lipid metabolism include bisphosphonates, Selective Estrogen Receptor Modulators ; SERMs and activated vitamin D. Bisphosphonates have little, if any, effect on lipid metabolism, while they are suggested to improve glucose metabolism, via osteocalcin or adiponectin. SERMs are shown to decrease serum triglycerides and LDL cholesterol levels, and increase HDL cholesterol level. To date, SERMs are not proven to reduce the risk of coronary events. From nutritional point of view, studies suggest that vitamin D may improve lipid and glucose metabolism, whereas its therapeutic effect on lifestyle related diseases is unknown.
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