AI Article Synopsis
- Systemic mastocytosis is a rare disorder characterized by an abnormal increase of mast cells in the body, often leading to health complications, but its specific incidence in Greece is not well-known.
- The case presented involves a 72-year-old man diagnosed with mastocytosis after finding high levels of mast cells in his intestine and elevated levels of tryptase in his blood.
- The patient meets the diagnostic criteria for systemic indolent mastocytosis and is currently receiving treatment with antihistamines, remaining without symptoms.
Article Abstract
Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor cell. It is a rare disorder with unknown incidence in Greece, with an estimate of 2 cases per year in Great Britain. We present a case of an asymptomatic, 72-year-old man who was found to have ileocolitis on endoscopy. Histology revealed mast cells in lamina propria >15 HPF and biochemistry showed high levels of serum total tryptase. Molecular testing was positive for the mutation Asp816Val in exon 17 of . The patient met one major and two minor criteria for the diagnosis of systemic indolent mastocytosis (according to WHO classification). He has been treated prophylactically with H- and H-histamine receptor antagonists and remains asymptomatic.
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