Purpose: Recently, the (Resolution Enhanced-) T1 insensitive steady-state imaging (TOSSI) approach has been proposed for the fast acquisition of T2 -weighted images. This has been achieved by balanced steady-state free precession (bSSFP) imaging between unequally spaced inversion pulses. The purpose of this work is to present an extension of this technique, considerably increasing both the efficiency and possibilities of TOSSI.
Theory And Methods: A radial trajectory in combination with an appropriate view-sharing reconstruction is used. Because each projection traverses the contrast defining k-space center, several different contrasts can be extracted from a single-shot measurement. These contrasts include various T2 -weightings and T2 /T1 -weighting if an even number of inversion pulses is used, while an odd number allow the generation of several images with predefined tissue types cancelled.
Results: The approach is validated for brain and abdominal imaging at 3.0 Tesla. Results are compared with RE-TOSSI, bSSFP, and turbo spin-echo images and are shown to provide similar contrasts in a fraction of scan time. Furthermore, the potential utility of the approach is illustrated by images obtained from a brain tumor patient.
Conclusion: Radial T1 sensitive and insensitive steady-state imaging is able to generate multiple contrasts out of one single-shot measurement in a short scan time.
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http://dx.doi.org/10.1002/mrm.25337 | DOI Listing |
Cell Mol Life Sci
December 2024
Department of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Macrophages are versatile myeloid leukocytes with flexible cellular states to perform diverse tissue functions beyond immunity. This plasticity is however often hijacked by diseases to promote pathology. Scanning kinetics of macrophage states by single-cell transcriptomics and flow cytometry, we observed atopic dermatitis drastically exhausted a resident subtype S1.
View Article and Find Full Text PDFNat Commun
October 2024
Department of Chemistry, State Key Laboratory of Extreme Photonics and Instrumentation, Zhejiang Key Laboratory of Excited State Energy Conversion and Storage, Zhejiang University, Hangzhou, China.
2D perovskites hold immense promise in optoelectronics due to their strongly bound electron-hole pairs (i.e., excitons).
View Article and Find Full Text PDFVision Res
November 2024
Department of Ophthalmology and Visual Sciences, Salt Lake City, UT 84132, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT 84132, USA; Department of Neurobiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. Electronic address:
The trabecular meshwork (TM) regulates intraocular pressure (IOP) by converting biochemical and biomechanical stimuli into intracellular signals. Recent electrophysiological studies demonstrated that this process is mediated by pressure sensing ion channels in the TM plasma membrane while the molecular and functional properties of channels that underpin ionic homeostasis in resting cells remain largely unknown. Here, we demonstrate that the TM resting potential is subserved by a powerful cationic conductance that disappears following Na removal and substitution with choline or NMDG.
View Article and Find Full Text PDFHeliyon
August 2024
Department of Electrical Engineering, City University of Hong Kong, Kowloon, Hong Kong Special Administrative Region of China.
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