Erythema nodosum leprosum (ENL) or Type-2 lepra reaction is a manifestation of type-III hypersensitivity response, and usually occurs in certain cases of lepromatous and borderline lepromatous leprosy. ENL may present as widespread crops of erythematous, inflamed nodules and papules. Rare variants of ENL mimicking pemphigus or Sweet's syndrome (SS) have been documented. Here, we report an unusual case of persistent ENL in a 52-year-old lady, which we could diagnose with the help of skin biopsy and histopathological examination.
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BMJ Case Rep
December 2024
Department of Ophthalmology, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
A young male in his late 20s presented with brownish discolouration of the conjunctiva and periocular area of both eyes. He was diagnosed as a case of lepromatous leprosy with recurrent type II lepra reaction 4 years ago and was started on multidrug therapy-multi bacillary, which included clofazimine. The best-corrected visual acuity was 20/20 in both eyes.
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December 2024
Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Leprosy remains a persistent health challenge in endemic regions with cases rising in non-endemic regions such as North America. Patients with leprosy present with a variety of symptoms including limited skin lesions in tuberculoid leprosy to extensive lesions and high bacterial proliferation in lepromatous leprosy. This case report details a 77-year-old Canadian man of South Asian descent with lepromatous leprosy and Lucio's phenomenon in Western Canada.
View Article and Find Full Text PDFBorderline lepromatous leprosy with Type 1 reaction poses significant diagnostic challenges due to overlapping clinical features. Early recognition and differentiation are crucial, especially in endemic regions like Mexico, to ensure prompt, appropriate management and prevent complications. Accurate diagnosis requires a multidisciplinary approach integrating clinical, histopathological, and microbiological data.
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January 2025
Service of Dermatology "Dr. Mario Magaña Lozano' of the Hospital General de México "Dr. Eduardo Liceaga', S.S. (Ministry of Health)/Faculty of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City, México.
Mycobacterium leprae and M. lepromatosis, the causative agents of leprosy, have left a mark on human history. Despite advances in health care, leprosy continues to affect millions worldwide, often leading to complications, mostly neural, due to delayed diagnosis and treatment.
View Article and Find Full Text PDFInfez Med
December 2024
Infectious Disease Division, Department of Internal Medicine, Faculty of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, & King Fahad hospital of the University, Al-Khobar, Saudi Arabia.
Leprosy, a chronic infectious disease caused by complex, remains a significant global health concern despite being curable with multidrug therapy. Delayed diagnosis is common, particularly in non-endemic regions or when presenting with atypical symptoms. This can lead to missed opportunities for early intervention, potential disabilities, and increased transmission.
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