AI Article Synopsis
- Caspases are important enzymes that play a key role in the process of programmed cell death, known as apoptosis, and are found across various multicellular organisms.
- Detecting apoptosis is challenging because dying cells are quickly cleared away by other cells, making it hard to study the process directly.
- The chapter introduces a new method using a genetically encoded fluorescent probe that allows researchers to visualize caspase activation in live cells, aiding the study of apoptosis.
Article Abstract
Caspases, which constitute a family of cysteine proteases, are highly conserved in multicellular organisms and function as a central player in apoptosis. The detection of apoptosis is intrinsically difficult because dying cells are rapidly removed from tissues by phagocytosis. Thus, the development of a method for detecting caspase activation is critical for the in vivo study of apoptosis. In this chapter, we describe a genetically encoded fluorescent probe for live imaging of caspase activation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/B978-0-12-417158-9.00012-1 | DOI Listing |
Publication Analysis
Top Keywords
caspase activation
12
fluorescent probe
8
vivo monitoring
4
monitoring caspase
4
activation fluorescence
4
fluorescence resonance
4
resonance energy
4
energy transfer-based
4
transfer-based fluorescent
4
probe caspases
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!