AI Article Synopsis
- The cFAMC method combines forward and adjoint Monte Carlo techniques to analyze how light interacts with 3-D tissue, providing a way to calculate how sensitive the optical measurements are to various tissue properties.
- This method includes a detailed computational framework that evaluates light field distributions in tissues with varying scattering properties, highlighting the influence of factors like source-detector distance and orientation.
- Results from the study underscore the importance of angular discretization in enhancing the accuracy of absorption sensitivity profiles, offering valuable insights for advancing optical imaging techniques.
Article Abstract
We present a coupled forward-adjoint Monte Carlo (cFAMC) method to determine the spatially resolved sensitivity distributions produced by optical interrogation of three-dimensional (3-D) tissue volumes. We develop a general computational framework that computes the spatial and angular distributions of the forward-adjoint light fields to provide accurate computations in mesoscopic tissue volumes. We provide full computational details of the cFAMC method and provide results for low- and high-scattering tissues probed using a single pair of optical fibers. We examine the effects of source-detector separation and orientation on the sensitivity distributions and consider how the degree of angular discretization used in the 3-D tissue model impacts the accuracy of the resulting absorption sensitivity profiles. We discuss the value of such computations for optical imaging and the design of optical measurements.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073599 | PMC |
| http://dx.doi.org/10.1117/1.JBO.19.6.065003 | DOI Listing |
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