Choriocarcinoma in the second trimester with a normal appearing live fetus is rare. A primigravida presented at 24 weeks' gestation with 5 days of worsening dyspnea and multiple widespread small lung nodules. Pelvic ultrasound revealed a normal intrauterine live singleton fetus with an extrauterine mass. Gestational hypertension progressed to preeclampsia with severe features and onset of vaginal bleeding. Cesarean delivery was undertaken with liveborn delivery and removal of an intrauterine mass confirmed to be choriocarcinoma. Postpartum treatment with multi-agent chemotherapy was initiated. The newborn thrived; the mother has no evidence of residual disease.
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http://dx.doi.org/10.3109/14767058.2014.939623 | DOI Listing |
Biol Reprod
January 2025
Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO USA.
The mechanistic target of rapamycin (mTOR) system is vital to placental development, formation, and function. Alterations in this system in the placenta have been associated with altered fetal growth. However, changes in placental mTOR signaling across gestation are poorly understood.
View Article and Find Full Text PDFPostpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide, which is often attributed to retained placenta (RP) after delivery. There are no biomarkers currently used to predict a risk of developing RP/PPH prior to labor. The objective of this study was to determine relationships between placental biomarkers measured in the first and second trimesters and proxy measures of postpartum blood loss relative to preeclampsia status in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) dataset.
View Article and Find Full Text PDFCase Rep Womens Health
March 2025
Dilla University, College of Medicine and Health Sciences, Department of Obstetrics and Gynecology, Dilla, Ethiopia.
Uterine rupture is a rare but serious complication that predominantly occurs in the third trimester of pregnancy. It is exceptionally uncommon in the second trimester, particularly in the presence of uterine anomalies such as a bicornuate uterus or uterus didelphys. This case report presents a significant instance of second-trimester uterine rupture associated with a bicornuate uterus, resulting in a life-threatening intra-abdominal hemorrhage of approximately 4000 mL.
View Article and Find Full Text PDFJ Med Ultrasound
February 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Ortahisar, Trabzon, Turkey.
Background: The effect of congenital cardiac malformation on fetal cerebral circulation has not been well known. This study aimed to compare the cerebral blood circulation of fetuses with congenital heart disease (CHD) with healthy fetuses.
Methods: This prospective cohort study included 37 pregnant women who presented to the gynecology and obstetrics department of department of Farabi Hospital, Faculty of Medicine, Karadeniz Technical University for anomaly screening in the second trimester.
J Affect Disord
January 2025
Department of Psychiatry and Medical Psychology, OLVG, P.O. Box 95500, 1090 HM Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit van Amsterdam, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands; Amsterdam Public Health, Mental Health Programme, Amsterdam, the Netherlands.
Background: Postpartum depression is common and may be linked to antepartum insomnia, a potentially modifiable risk factor. We examine the association between insomnia- and postpartum depression symptoms, considering whether psychiatric vulnerability moderates this link.
Method: Participants completed the Insomnia Severity Index during trimester two and three and the Hospital Anxiety and Depression questionnaire postpartum.
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