Renal transplantation (RT) is the best option for patients with end-stage renal disease, but the half-life is limited to a decade due to progressive deterioration of renal function and transplant failure from chronic allograft nephropathy (CAN), which is the leading cause of transplant loss. Extensive research has been done to understand the pathogenesis, the biological pathways of fibrogenesis, and potential therapeutic targets for the prevention and treatment of CAN. Despite the advancements in the immunosuppressive agents and patient care, CAN continues to remain an unresolved problem in renal transplantation. The aim of this paper is to undertake a comprehensive review of the literature on the pathogenesis, biological pathways of RT fibrogenesis, and potential therapeutic targets for the prevention and therapy of CAN.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058292 | PMC |
| http://dx.doi.org/10.1155/2014/482438 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessing the distribution pattern of Saussurea medusa under climate change using an optimized MaxEnt model in Qinghai-Xizang Plateau.
Environ Monit Assess
January 2025
Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, Qinghai, China.
Saussurea medusa is a rare alpine plant with significant medicinal value. To better understand the changes in its habitat in the context of climate change, this study used an optimized MaxEnt model to predict the current and future habitat of S. medusa under four shared socioeconomic pathways (SSPs) across three time periods (current, mid-century, and end-century) based on three climate system models.
View Article and Find Full Text PDFAlginate coated mesoporous silica nanoparticles as oral delivery carrier of curcumin and quercetin to colon cancer: preparation, optimization, characterization, and anticancer activity.
Drug Deliv Transl Res
January 2025
Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Penang, Malaysia.
The synergistic bioactive effect of polyphenols can enhance the development of functional foods to prevent chronic diseases such as cancer. Curcumin and quercetin have been shown to possess anticancer properties. The combination of curcumin and quercetin has been shown to provide synergistic effects against cancer cell proliferation.
View Article and Find Full Text PDFBibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024.
Discov Oncol
January 2025
School of Rehabilitation Medicine and Health Care, Hunan University of Medicine, No. 492 Jinxi South Road, Huaihua, 418000, China.
Background: Prostate cancer (PCa) ranks as the second most common disease among men and the fourth most prevalent cancer worldwide. Enhanced glycolysis and excessive lactate secretion are recognized as critical factors driving the progression of various cancers. This study systematically investigated the research trends associated with glycolysis in PCa through bibliometric analysis.
View Article and Find Full Text PDFSynthetic biology meets Aspergillus: engineering strategies for next-generation organic acid production.
World J Microbiol Biotechnol
January 2025
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210023, People's Republic of China.
Organic acids constitute a vital category of chemical raw materials. They have extensive applications in industries such as polymers, food, and pharmaceuticals. Currently, industrial production predominantly relies on microbial fermentation.
View Article and Find Full Text PDFLipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes.
Commun Biol
January 2025
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, China.
Hibernation is a necessary means for animals to maintain survival while coping with low temperatures and food shortages. While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. In order to provide insights into the energy metabolism and potential microbial regulatory mechanisms in hibernating snakes, the serum, liver, gut content samples were measured by multi-omic methods.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!