Objective: To determine the value of random urinary protein to creatinine ratio (UPCR) for diagnosis of proteinuria in pregnant women with preeclampsia. Preeclampsia is the most common complication of pregnancy and one of the main causes of maternal mortality. So, early diagnosis of preeclampsia is very important.
Materials And Methods: In this cross-sectional study 66 pregnant women suspected preeclampsia at ≥24 week of gestational age and BP ≥ 140/90 mm/Hg were checked by two urine samples of 10am and 4pm to determine random UPCR, as well as a 24-hour urine sample to evaluate 24-hour protein excretion.
Results: The result revealed that 74.2% of the studied population had significant proteinuria. There was a correlation between UPCR and 24-hour urine protein excretion. Pearson's correlation coefficient was 0.502 at 10am and 0.428 at 4pm. The best cutoff for the random urine protein to creatinine ratio at 10am was 0.470 with sensitivity and specificity equal to 87.5% and 84.2%, respectively. The best cutoff for the random UPCR at 4pm was 0.595 with sensitivity and specificity equal to 91.7% and 94.7%, respectively.
Conclusion: Result of 24-hour urine collection showing random UPCR is considered as an appropriate situated method for emergency time.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064777 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Effect of oral potassium supplementation on urinary potassium excretion and its diagnostic value for primary aldosteronism.
Clin Exp Hypertens
December 2025
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Objectives: We aimed to: (1) explore the effect of oral potassium supplementation on urinary potassium excretion, and (2) evaluate the value of urinary potassium-related indicators in distinguishing primary aldosteronism (PA) from non-PA patients.
Design And Methods: A prospective study of 20 patients with hypertension and hypokalemia caused by renal potassium loss between November 2023 and April 2024 was conducted. Demographic features, 24-hour urine collection before and after potassium supplementation were all collected.
Combination Oxylanthanum Carbonate and Tenapanor Lowers Urinary Phosphate Excretion in Rats.
Kidney360
January 2025
Unicycive Therapeutics, Los Altos, CA, United States.
Background: This study evaluated the combined effects of oxylanthanum carbonate (OLC), an investigational phosphate binder, and tenapanor, an approved sodium/hydrogen exchanger 3 (NHE3) inhibitor that reduces paracellular phosphate absorption, on urinary phosphate excretion in rats on a high phosphorus diet.
Methods: Sixty-four male Sprague Dawley rats were randomized into eight groups: vehicle; tenapanor (0.15 mg/kg) only; OLC (0.
The pathophysiology of dystonia in Wilson disease (WD) is complex and poorly understood. Copper accumulation in the basal ganglia, disrupts dopaminergic pathways, contributing to dystonia's development via neurotransmitter imbalance. Despite advances in diagnosis and management, WD with dystonia remains a challenging condition to treat.
View Article and Find Full Text PDFA comparative analysis in monitoring 24-hour urinary copper in wilson disease: sampling on or off treatment?
Orphanet J Rare Dis
January 2025
Internal Medicine IV, Department of Gastroenterology, University Hospital Heidelberg, INF 410, Heidelberg, 69120, Germany.
Background & Aim: Twenty-four-hour urinary copper excretion (24 h-UCE) is the standard diagnostic tool for dose adjustments in maintenance therapy in Wilson disease (WD) patients. Guidelines lack data if both variants of 24 h-UCE measurement (with or without 48 h of treatment interruption) are equally interpretable.
Methods: Eighty-four patients with a confirmed diagnosis of WD treated with chelators (50% of patients with D-Penicillamine and 50% with trientine) and with pairwise 24-h-UCE values on-therapy and off-therapy were included in the analysis.
Diagnosis of arginine vasopressin deficiency in a patient with 10 years of polyuria and polydipsia following an Epstein-Barr virus infection.
BMJ Case Rep
January 2025
Biochemistry, North West Anglia NHS Foundation Trust, Peterborough, UK.
Polyuria-polydipsia syndrome is composed of arginine vasopressin deficiency, arginine vasopressin resistance and primary polydipsia and are characterised by severe polyuria with hypotonic urine. The water deprivation test is commonly used to indirectly assess the vasopressin response to water deprivation. We report a woman in her 20s who demonstrated severe polyuria (11-12 L/day) on submitting a 24-hour urine sample for analysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!