Intermedin functions systemically as a potent vasodilator and its plasma levels have been shown to be elevated in patients with acute myocardial infarction. This study aimed to evaluate the prognostic value of plasma intermedin level in the patients with ST-segment elevation acute myocardial infarction. Plasma intermedin concentrations of 128 patients and 128 healthy controls were determined using a radioimmunoassay. Patients were followed up for 6 months for major adverse cardiovascular events (MACE) consisting of cardiovascular mortality, reinfarction, hospitalization for decompensated heart failure, and lift-threatening arrhythmia. The association of plasma intermedin levels with MACE was investigated by univariate and multivariate analyses. Plasma intermedin levels were significantly higher in patients than in healthy subjects. Elevated plasma level of intermedin was identified as an independent predictor of MACE. Receiver operating characteristic curve analysis showed that plasma intermedin levels had high predictive value for MACE. Moreover, its predictive value was similar to Global Registry of Acute Coronary Events scores' based on area under curve. Meantime, it obviously improved Global Registry of Acute Coronary Events scores' predictive value in a combined logistic-regression model. In multivariate Cox's proportional hazard analysis, plasma intermedin level emerged as an independent predictor of MACE-free survival. Thus, our results suggest that high plasma intermedin level is associated with poor outcomes of patients and may be a useful prognostic biomarker in ST-segment elevation acute myocardial infarction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.peptides.2014.06.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Femoral Artery Infusion of αMSH Increases Muscle Thermogenesis and Promotes Glucose Uptake in Ovariectomized Ewes.
Endocrinology
November 2024
Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
Article Synopsis
- The melanocortin system plays a crucial role in controlling energy balance and weight regulation, with recent findings indicating its effects on peripheral tissues like skeletal muscle, independent of the brain or SNS.
- Infusing α-melanocyte-stimulating hormone (αMSH) directly into the femoral artery significantly increased heat production in skeletal muscle, while not affecting food intake, demonstrating its local action in energy expenditure.
- The study also revealed that αMSH infusion enhanced mitochondrial function, increased glucose uptake in skeletal muscle, and showed that blocking SNS with certain drugs did not impact αMSH's effects, highlighting its unique role in energy regulation.
Assessing the effects of ex vivo hormonal exposure on oxidative responses in equine leukocytes: A preliminary study.
Vet Immunol Immunopathol
October 2024
Department of Large Animal Medicine, University of Georgia College of Veterinary Medicine, Athens, GA, USA. Electronic address:
Breed differences exist between horses and ponies in circulating concentrations of several hormones, notably ACTH and insulin. These hormones regulate stress and metabolic responses, but in other species, they also impact leukocyte oxidant responses. The effects of these hormones on equine leukocytes have not been evaluated to date.
View Article and Find Full Text PDFIntraperitoneal administration of α-melanocyte stimulating hormone (α-MSH) suppresses food intake and induces anxiety-like behavior via the brain MC4 receptor-signaling pathway in goldfish.
J Neuroendocrinol
November 2024
Laboratory of Regulatory Biology, Graduate School of Innovative Life Sciences, University of Toyama, Toyama, Japan.
α-Melanocyte stimulating hormone (α-MSH) is a peptide hormone released from the intermediate lobe of the pituitary which regulates body pigmentation. In addition to the pituitary, α-MSH is also produced in the midbrain, and exerts both anorexigenic and an anxiogenic actions. Acyl ghrelin and cholecystokinin are peripheral hormones derived from the digestive tract which affect the brain to control food intake and feeding behavior in vertebrates.
View Article and Find Full Text PDFEffect of Hepatic and Renal Impairment on the Pharmacokinetics of Dersimelagon (MT-7117), an Oral Melanocortin-1 Receptor Agonist.
Clin Pharmacol Drug Dev
July 2024
Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan.
Article Synopsis
- - Dersimelagon is a selective medication being tested for treating certain rare disorders like erythropoietic protoporphyria and systemic sclerosis, but it is heavily processed by the liver, raising concerns for patients with liver issues.
- - Two studies were conducted to assess how liver and kidney impairments affect the drug's pharmacokinetics, which involves how the drug is absorbed and metabolized in the body.
- - Results showed that while mild liver impairment had similar effects on the drug, moderate impairment increased its concentration in the bloodstream significantly, and renal impairment also affected drug levels, though Dersimelagon was generally well tolerated among participants.
The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome.
Ann Neurol
April 2024
Department of Chronic Disease Epidemiology, Yale University, New Haven, CT, USA.
Objective: Based upon similarities between the urge to move and sensory discomfort of restless legs syndrome (RLS) and properties of melanocortin hormones, including their incitement of movement and hyperalgesia, we assessed plasma and cerebrospinal fluid (CSF) α-melanocyte-stimulating hormone (α-MSH) and β-endorphin in RLS patients and controls.
Methods: Forty-two untreated moderate-to-severe RLS patients and 44 matched controls underwent venipuncture at 19:00, 20:30, and 22:00; 37 RLS and 36 controls had lumbar puncture at 21:30. CSF and plasma were analyzed for pro-opiomelanocortin (POMC), adrenocorticotropin hormone (ACTH), α-MSH, β-MSH, and β-endorphin by immunoassay.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!