AI Article Synopsis
- The study investigates how acute and repeated stress affects catecholamine levels, gene expression, and receptor proteins in the right ventricle of rats, comparing these effects to previously observed changes in the left ventricle.
- In the right ventricles, levels of noradrenaline and adrenaline increased, but there were no significant changes in β1-AR receptors, while β2-AR gene expression significantly decreased and β3-AR expression increased after repeated stress.
- The findings highlight the importance of receptor balance between the left and right ventricles in maintaining heart stability under stress, suggesting that decreased β2-AR may play a crucial role in heart physiology.
Article Abstract
The left and right ventricles fulfill different role in heart function. Here we compare chamber specific changes in local catecholamine concentrations; gene expression and the receptor protein amount of all three β-adrenoceptors (β-AR) in rat right heart ventricles exposed to acute (1 session) and repeated (7 sessions) immobilization stress (IMMO) vs. previously observed changes in left ventricles. Density of muscarinic receptors as main cardio-inhibitive receptors was also measured. In the right ventricles, noradrenaline and adrenaline were increased. No β1-AR changes were observed, in spite of the increased sympathetic activity. On the other hand, we have found a decrease of β2-AR gene expression (reduction to 30%) after 7 IMMO and protein (to 59%) after 1 IMMO. β3-AR gene expression was increased after 7 IMMO. Muscarinic receptor density was not changed. When comparing correlation in left and right ventricles, there was strong correlation between adrenaline and β2-AR gene expression, protein and β3-AR gene expression in the left ventricles while only correlation between adrenaline and β2-AR mRNA and protein in the right ventricles was found. Our results show that maintenance of cardiac homeostasis under stress conditions are to a great extent achieved by a balance between different receptors and also by a balanced receptor changes in left vs. right ventricles. Taken together, decrease of cardio-stimulating β2-AR represents a new important mechanism by which β2-AR contributes to the heart physiology.
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| http://dx.doi.org/10.4149/gpb_2014002 | DOI Listing |
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