Copper-catalyzed nucleophilic trifluoromethylation of benzylic chlorides.

Org Biomol Chem

Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656, Japan.

Published: August 2014

Reactions of primary and secondary benzylic chlorides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(i) thiophene-2-carboxylate (CuTC) have been found to give the corresponding benzylic trifluoromethylated products in good to high yields.

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Source
http://dx.doi.org/10.1039/c4ob00957fDOI Listing

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