Twenty patients with severe aplastic anemia (SAA) were treated with low doses (1-5 mg/kg/day) of a high-potency antithymocyte globulin (ATG) produced in Mexico, shown to have at least a 10-fold potency as compared with other globulins of commercial sources. Patients received ATG within a 10-day period, every other day (5 doses) at a dose of 1 mg/kg/day (4 courses), 2 mg/kg/day (12 courses) or 5 mg/kg/day (8 courses). Four patients received 2 consecutive courses of different doses of ATG. A response rate of 42% was recorded in the group, assessed by means of increases in reticulocytes, granulocytes or platelets. One patient showed a complete remission. The 570-day survival of the group was 51%. It is concluded that the domestically produced ATG is useful in the treatment of some patients with SAA in Mexico.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000205529 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy and safety of praziquantel plus artemisinin-based combinations versus praziquantel in the treatment of Kenyan children with infection: open-label, randomized, head-to-head, non-inferiority trial.
Antimicrob Agents Chemother
December 2024
Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Praziquantel alone is insufficient for the control of schistosomiasis due to poor efficacy against juvenile worms and increasing concerns about the risk of drug resistance. We compared the efficacy and safety of praziquantel combined with four different artemisinin-based combinations to praziquantel alone in treating infection in Kenyan children. In this randomized, open-label, five-arm, head-to-head, non-inferiority trial, children (aged 9-15 years) with infection according to duplicate Kato Katz thick smears from a stool sample in the Mwea irrigation scheme of central Kenya, were enrolled.
View Article and Find Full Text PDFClinical, Biochemical, and Histological Manifestations and Long-Term Outcomes of Renal Sarcoidosis - A Single Center Study.
Indian J Nephrol
July 2024
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Background: Renal involvement in sarcoidosis is rare. We evaluated the pattern of renal involvement in sarcoidosis, its clinical course, renal histology, and response to treatment.
Materials And Methods: We retrospectively analyzed the data of all cases with sarcoidosis exhibiting renal involvement referred to our department between January 2010 and December 2021.
Pharmacokinetic analysis of crushed venetoclax tablets combined with azacitizine for recurrent pediatric acute myeloid leukemia (AML).
Cancer Chemother Pharmacol
December 2024
Department of Hematology / Oncology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Article Synopsis
- A combination therapy of venetoclax (VEN) and azacytidine (AZA) shows promise for treating pediatric acute myeloid leukemia (AML), but limited clinical data exists for this age group.
- Two young patients with recurrent AML received VEN/AZA, but their plasma concentrations of VEN were significantly lower than optimal levels at standard dosages.
- Safe usage led to varying disease stability, with one patient maintaining stable disease for two months and the other for six months, highlighting challenges in achieving effective drug concentrations in pediatric cases.
Pediatric trichinosis: A case report.
Int J Surg Case Rep
December 2024
Addis Ababa University, College of Health Sciences, Ethiopia. Electronic address:
Background: Trichinellosis is a zoonosis, caused by roundworms of the genus Trichinella. Domestic pigs, wild boars, bears, rodents and horses are reservoir animals. We report a case of neck trichinosis presenting as lateral neck swelling.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!