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Use of Granulocyte Transfusions in the Management of Severe Infections Among Children with Neutropenia.
J Pers Med
November 2024
Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Infections remain the leading cause of mortality among neutropenic patients with haematologic malignancies, making effective infection management crucial. Achieving a sufficient neutrophil count is essential for the elimination of pathogens. Granulocyte concentrate (GC) can be a treatment option for neutropenic patients with severe infections.
View Article and Find Full Text PDFSurvey about target temperature and thermal management in intensive care for severe thermal trauma in burn centres of Germany, Austria and Switzerland.
Burns
November 2024
Department of Anaesthesiology and Critical Care Medicine, Merheim Medical Center, University of Witten / Herdecke, Cologne, Germany; German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany. Electronic address:
Burn trauma induces hypermetabolism and alters thermoregulation resulting in elevated body temperature. Because patients with burns are prone to heat loss and hypothermia, maintaining physiologic body temperature is important. However, optimal target temperature is widely unknown because thermoregulation of burn trauma has mainly been studied in the previous century, when treatment concepts differed from current era.
View Article and Find Full Text PDFPerformance of the LifeScale automated rapid phenotypic antimicrobial susceptibility testing on Gram-negative rods directly from positive blood cultures.
J Clin Microbiol
December 2024
UofL Healthcare System, Louisville, Kentucky, USA.
Article Synopsis
- Rapid antimicrobial susceptibility testing (rAST) from blood cultures is crucial for selecting effective antibiotics for bloodstream infections, with the LifeScale system offering a promising new approach.
- LifeScale utilizes microfluidic sensors and mechanical resonators to quickly analyze individual microbes and deliver reliable rAST results in under 5 hours, outpacing standard methods.
- Notably, LifeScale addresses challenges with polymicrobial cultures and shows strong agreement with the current standard of care, potentially allowing for quicker clinical decision-making without the need for confirmatory tests.
A dose-adjusted, open-label, pilot study of the safety, tolerability, and pharmacokinetics of STC3141 in critically ill patients with sepsis.
Pharmacol Res Perspect
October 2024
Grand Medical Pty Ltd, St Leonards, New South Wales, Australia.
Increased circulating histones correlate with sepsis severity and are a potential therapeutic target. Pre-clinical studies showed benefit with a histone-neutralizing polyanion molecule (STC3141). We aimed to investigate the safety, tolerability, and pharmacokinetics of STC3141 in critically ill patients with sepsis.
View Article and Find Full Text PDFGBS vaccines in the UK: a round table discussion.
F1000Res
August 2024
St George's University of London, London, SW17 0RE, UK.
Background: Group B streptococcus (GBS) remains a leading cause of infant sepsis, meningitis and death despite intrapartum antibiotic prophylaxis. A vaccine is urgently required, and two candidates are in advanced clinical trials. For successful GBS vaccine implementation, especially if a vaccine is licensed based on an immunological threshold, there must be cross-sector engagement, effective advocacy, robust plans for phase IV studies and equitable access.
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