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Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review. | LitMetric

Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review.

Emerg Themes Epidemiol

London School of Hygiene & Tropical Medicine, Faculty of Epidemiology and Population Health, Keppel Street, London WC1E 7HT, UK.

Published: June 2014

AI Article Synopsis

Article Abstract

Background: The study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings.

Objective: To review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents.

Methods: A review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE.

Results: Studies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood) showed consistent associations with non-atopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects.

Conclusions: More research using standardized methodology is needed on the causes of non-atopic asthma.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068161PMC
http://dx.doi.org/10.1186/1742-7622-11-5DOI Listing

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