Unlabelled: Pitch elevation surgery is most often indicated to assist male-to-female transgendered individuals seeking a more feminine voice quality. Behavioral therapy is primary management but if the desired voice quality is not achieved, surgery is offered. Procedures described that raise vocal pitch alter one or more of the main parameters known to physiologically control pitch; vocal fold tension, length, and mass.
Objective: Web formation with injection augmentation significantly raises vocal pitch in male-to-female transgendered individuals.
Study Design: Retrospective cohort study. This report describes the voice results after anterior web formation with injection augmentation to reduce vocal fold length in a series of 10 transgendered patients.
Methods: Retrospective review of male-to-female transgendered patients referred to St. Michaels Hospital Voice Clinic, Toronto, Canada for pitch elevation was carried out including demographic data, preoperative and postoperative acoustic data and videostroboscopic evaluation.
Results: Comparison between preoperative to postoperative acoustic measures demonstrated a mean increase in fundamental frequency of 110 Hz after web formation. Perturbation measures and pitch range were unchanged from before surgery to after surgery.
Conclusion: This novel modification for endoscopic anterior web formation has been shown to be a successful procedure for permanent elevation of pitch with little or no morbidity.
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http://dx.doi.org/10.1016/j.jvoice.2014.05.002 | DOI Listing |
BMJ Open
January 2025
Documentation and Scientific Information Service, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.
Introduction: This review aims to synthesise research evidence regarding biomarkers in the synovial fluid that may predict the risk of post-traumatic osteoarthritis (PTOA) in young adults. Considering the high prevalence of knee joint injuries, particularly among youth sports athletes, this review will focus on anterior cruciate ligament and/or meniscal ruptures. These injuries are highly associated with PTOA, with studies indicating that even with surgical reconstruction, 50%-80% of affected individuals develop knee PTOA within a 10-year follow-up.
View Article and Find Full Text PDFElife
January 2025
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Junior Research Group Synthetic Microbiology, Jena, Germany.
Mycofactocin is a redox cofactor essential for the alcohol metabolism of mycobacteria. While the biosynthesis of mycofactocin is well established, the gene , which encodes an oxidoreductase of the glucose-methanol-choline superfamily, remained functionally uncharacterized. Here, we show that MftG enzymes are almost exclusively found in genomes containing mycofactocin biosynthetic genes and are present in 75% of organisms harboring these genes.
View Article and Find Full Text PDFFront Oncol
January 2025
Department of Oncology, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, China.
Background: Abnormal energy metabolism is a prominent characteristic of cancers. Increasing evidence has suggested the involvement of glucose metabolism reprogramming in the progression of breast cancer (BC). This article aims to provide a comprehensive overview of glucose metabolism reprogramming in BC through a bibliometric analysis.
View Article and Find Full Text PDFJ Comput Chem
January 2025
Laboratory of Structural Proteomics, Institute of Biomedical Chemistry, Pogodinskaya, Moscow, Russia.
The proteins expressed during the cell cycle determine cell function and ensure signaling pathway activation in response to environmental influences. Developments in structural biology, biophysics, and bioinformatics provide information on the structure and function of particular proteins including that on the structural changes in proteins due to post-translational modification (PTM) and amino acid substitutions (AAS), which is essential for understanding protein function and life cycle. These are PTMs and AASs that often modulate the function and alter the stability and localization of a protein in a cell.
View Article and Find Full Text PDFCancer Cell Int
January 2025
Department of Toxicology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
Background: Cancer remains a leading cause of death worldwide. Environmental factors, specifically endocrine-disrupting chemicals (EDCs), like phthalates, are increasingly being linked to cancer development. Phthalates, widely used in consumer products, can activate the aryl hydrocarbon receptor (AhR).
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