AI Article Synopsis
- Three premature babies exposed in utero to prostaglandin synthetase inhibitors (PSI) and corticosteroids experienced renal dysfunction at birth.
- One infant had transient water and sodium retention leading to uraemia, while twins suffered from severe acute renal failure and high potassium levels (hyperkalaemia).
- The renal issues may stem from disrupted prostaglandin-mediated adaptation to stress due to PSI exposure, and the corticosteroids could have played a role in inhibiting prostaglandin synthesis.
Article Abstract
Three cases of renal dysfunction at birth were observed in premature babies exposed in utero to prostaglandin synthetase inhibitors (PSI) and corticosteroids. Transient water and sodium retention with uraemia occurred in one patient, and severe acute renal failure with marked hyperkalaemia in twins. These findings may be due to impairment of prostaglandin (PG)-mediated renal adaptation to stress conditions after transplacental passage of PSI. Corticosteroids may also have affected PG synthesis inhibition.
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| http://dx.doi.org/10.1007/BF00444137 | DOI Listing |
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