Hormonal and neural mechanisms of food reward, eating behaviour and obesity.

Nat Rev Endocrinol

New York Obesity Research Center, Department of Medicine, Columbia University College of Physicians and Surgeons, P&S Box 30 DOM/NYORC, 630 West 168th Street, New York, NY 10032-3702, USA.

Published: September 2014

AI Article Synopsis

  • Research is examining the link between biological mechanisms and eating behavior, specifically focusing on the consumption of highly palatable foods.
  • Key hormones like leptin, ghrelin, and insulin are crucial in regulating food rewards as well as normal feeding behaviors.
  • The relationship between excessive eating (hyperphagia), obesity, and the brain's reward pathways suggests potential addictive qualities in food consumption, which could shed light on issues like binge eating and rising obesity rates.

Article Abstract

With rising rates of obesity, research continues to explore the contributions of homeostatic and hedonic mechanisms related to eating behaviour. In this Review, we synthesize the existing information on select biological mechanisms associated with reward-related food intake, dealing primarily with consumption of highly palatable foods. In addition to their established functions in normal feeding, three primary peripheral hormones (leptin, ghrelin and insulin) play important parts in food reward. Studies in laboratory animals and humans also show relationships between hyperphagia or obesity and neural pathways involved in reward. These findings have prompted questions regarding the possibility of addictive-like aspects in food consumption. Further exploration of this topic may help to explain aberrant eating patterns, such as binge eating, and provide insight into the current rates of overweight and obesity.

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Source
http://dx.doi.org/10.1038/nrendo.2014.91DOI Listing

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