AI Article Synopsis
- MicroRNAs (miRNAs) are small RNA molecules that help regulate gene expression by silencing specific genes after they are transcribed.
- Recent research emphasizes the importance of miRNAs in brain development and functions like synapse formation and memory, but the impact of neuronal activity on miRNA regulation hasn’t been as thoroughly investigated.
- The paper reviews how neuronal activity can influence miRNA levels and discusses the potential molecular processes behind the induction and degradation of miRNAs in response to brain activity.
Article Abstract
MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may fine-tune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132302 | PMC |
| http://dx.doi.org/10.14348/molcells.2014.0132 | DOI Listing |
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