IL-17 and TNF synergistically induce surface expression of IL-13R2 on primary lung fibroblasts, rendering them unresponsive to IL-13. Neutralizing antibodies to IL-13R2 restored IL-13-mediated signaling and transcriptome studies confirmed IL-13R2 is an IL-13 decoy receptor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186904 | PMC |
| http://dx.doi.org/10.1016/j.jaci.2014.05.019 | DOI Listing |
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