AI Article Synopsis
- - Zebrafish are commonly used in research to study human diseases due to their genetic similarities and the ability to manipulate their genes easily.
- - Various techniques exist for genetically altering zebrafish, resulting in numerous mutants across different genes, although proteomics (the study of proteins) has not been fully utilized in this context.
- - The review discusses existing proteomic studies and introduces initial research comparing protein changes in the intestines of ascl1a-/- mutants and wild-type zebrafish.
Article Abstract
The zebrafish (Danio rerio) is frequently being used to investigate the genetics of human diseases as well as resulting pathologies. Ease of both forward and reverse genetic manipulation along with conservation of vertebrate organ systems and disease causing genes has made this system a popular model. Many techniques have been developed to manipulate the genome of zebrafish producing mutants in a vast array of genes. While genetic manipulation of zebrafish has progressed, proteomics have been under-utilized. This review highlights studies that have already been performed using proteomic techniques and as well as our initial proteomic work comparing changes to the proteome between the ascl1a-/- and WT intestine.
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| http://dx.doi.org/10.1007/978-3-319-06068-2_15 | DOI Listing |
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