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Non-ketotic hyperglycaemia-induced hemichorea-hemiballism may represent glioma-like pattern on multimodal magnetic resonance imaging: can H spectroscopy help in the differentiation?
BJR Case Rep
November 2024
Department of Radiology, Zhongshan Hospital Affiliated to Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361004, China.
Non-ketotic hyperglycaemia (NKH)-induced hemichorea-hemiballismus (HC-HB) is an infrequent reversible condition observed in individuals with poorly controlled diabetes. In this report, we present a case of NKH-induced HC-HB exhibiting distinctive morphological and functional alterations on conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and H magnetic resonance spectroscopy (MRS), followed by subsequent monitoring. A 70-year-old male with a 20-year history of diabetes presented with severe unilateral involuntary movement.
View Article and Find Full Text PDFChanges to Dorsal Thalamic Metabolites and Thalamocortical Tract Fiber Injury in Patients with Cervical Spondylotic Myelopathy.
Magn Reson Med Sci
December 2024
Department of CTMRI, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Purpose: This study aims to assess thalamocortical tract fiber injury using diffusion-tensor imaging (DTI) and to characterize metabolic alterations in the dorsal thalamus with proton magnetic resonance spectroscopy (MRS) in patients with cervical spondylotic myelopathy (CSM).
Methods: A prospective study involved 98 CSM patients and 66 age-matched controls without neurological disease, recruited from May 2021 to December 2021. Neurological function was evaluated using the modified Japanese Orthopaedic Association (mJOA) score.
Investigating ITM2B-associated ataxia in a Taiwanese cerebellar ataxia cohort.
Ann Clin Transl Neurol
January 2025
Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Objective: The genetic causes of a significant number of patients with cerebellar ataxia remain unsolved. Variations in the ITM2B gene, typically linked to dominantly inherited dementia, can sometimes present with cerebellar ataxia as an early symptom. This study aims to investigate the role of ITM2B variations in a Taiwanese cohort with unsolved cerebellar ataxia.
View Article and Find Full Text PDFN-acetylaspartate mitigates pro-inflammatory responses in microglial cells by intersecting lipid metabolism and acetylation processes.
Cell Commun Signal
November 2024
Department of Biology, University of Rome Tor Vergata, Rome, 00133, Italy.
Background: Microglia play a crucial role in brain development and repair by facilitating processes such as synaptic pruning and debris clearance. They can be activated in response to various stimuli, leading to either pro-inflammatory or anti-inflammatory responses associated with specific metabolic alterations. The imbalances between microglia activation states contribute to chronic neuroinflammation, a hallmark of neurodegenerative diseases.
View Article and Find Full Text PDFSleep disturbance impaired memory consolidation via lateralized disruption of metabolite in the thalamus and hippocampus: A cross-sectional proton magnetic resonance spectroscopy study.
J Alzheimers Dis
December 2024
Department of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
Article Synopsis
- Memory consolidation during sleep depends on brain areas like the cortex, thalamus, and hippocampus, but how insomnia disrupts their metabolic patterns is still unclear.
- This study investigates how insomnia affects metabolites related to memory consolidation, using both clinical research with human participants and experimental studies with rats.
- Findings show that insomnia with mild cognitive impairment is associated with lower GABA levels, while sleep deprivation in rats worsens metabolic imbalances in the hippocampus, linking these changes to cognitive decline.
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