AI Article Synopsis
- Medulloblastomas, common malignant brain tumors in children, often lead to significant neurocognitive deficits in survivors due to treatment-related damage to the cerebellum and white matter.
- Functional neuroimaging has emerged as an important tool to study the cerebellum's role in cognitive functions, emphasizing its importance in language and emotional processing.
- The review suggests further clinical investigations are needed to understand how the posterior cerebellar lobes influence cognitive performance in children affected by medulloblastoma.
Article Abstract
Medulloblastomas are the most common malignant childhood brain tumors arising in the posterior fossa. Treatment improvements for these tumors have meant that there are a greater number of survivors, but this long-term patient survival has increased the awareness of resulting neurocognitive deficits. Impairments in attention, memory, executive functions, and intelligence quotient demonstrate that the cerebellum likely plays a significant role in numerous higher cognitive functions such as language, cognitive, and emotional functions. In addition, children with medulloblastoma not only have cerebellar lesions but also brain white matter damages due to radiation and chemotherapy. Functional neuroimaging, a noninvasive method with many advantages, has become the standard tool in clinical and cognitive neuroscience research. By reviewing functional neuroimaging studies, this review aims to clarify the role of the cerebellum in cognitive function and explain more clearly cognitive sequelae due to polytherapy in children with medulloblastoma. This review suggests that the posterior cerebellar lobes are crucial to maintaining cognitive performance. Clinical investigations could help to better assess the involvement of these lobes in cognitive functions.
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| http://dx.doi.org/10.3171/2014.5.PEDS13571 | DOI Listing |
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