AI Article Synopsis
- Researchers isolated several compounds from the leaves of Canarium patentinervium Miq. through a bioassay guided fractionation process.
- All isolated compounds showed antiacetylcholinesterase (AChE) activity, with syringic acid demonstrating the strongest inhibition.
- The compounds also exhibited moderate antileishmanial activity, indicating that Canarium patentinervium could be a promising source for developing treatments for neurodegenerative and parasitic diseases.
Article Abstract
In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin (1), scoparone (2), (+)-catechin (3), vomifoliol (4), lioxin (5), and syringic acid (6). All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC50 29.53 ± 0.19 μ g/mL). All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC50 163.30 ± 0.32 μ g/mL). Given the aforementioned evidence, it is tempting to speculate that Canarium patentinervium Miq. represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053261 | PMC |
| http://dx.doi.org/10.1155/2014/903529 | DOI Listing |
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- All isolated compounds showed antiacetylcholinesterase (AChE) activity, with syringic acid demonstrating the strongest inhibition.
- The compounds also exhibited moderate antileishmanial activity, indicating that Canarium patentinervium could be a promising source for developing treatments for neurodegenerative and parasitic diseases.
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