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| http://dx.doi.org/10.4300/JGME-D-14-00087.1 | DOI Listing |
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The dynamics of capillary flow in an open-channel system featuring trigger valves.
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December 2024
Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, 98195, USA.
Trigger valves are fundamental features in capillary-driven microfluidic systems that stop fluid at an abrupt geometric expansion and release fluid when there is flow in an orthogonal channel connected to the valve. The concept was originally demonstrated in closed-channel capillary circuits. We show here that trigger valves can be successfully implemented in open channels.
View Article and Find Full Text PDFChoosing the right frame: how context preferences facilitate subsequent decisions.
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December 2024
Division of Computational & Data Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Context shapes how we perceive choices and, therefore, how we decide between them. For instance, a large body of literature on the "framing effect" demonstrates that people become more risk-seeking when choices are framed in terms of losses. Despite this research, it remains unknown how people make choices between contexts and how these choices affect subsequent decision making.
View Article and Find Full Text PDFOxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury.
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December 2024
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
E-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use. To uncover pathways associated with EVALI, we examined cytokines, transcriptomic signatures, and lipidomic profiles in bronchoalveolar lavage fluid (BALF) from THC-EVALI patients. At a single center, we prospectively enrolled mechanically ventilated patients with EVALI from THC-containing products (N = 4) and patients with non-vaping acute lung injury and airway controls (N = 5).
View Article and Find Full Text PDFBayesian modeling of HFC production pipeline suggests growth in unreported CFC by-product and feedstock production.
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Earth Commons, Georgetown University, Washington, DC, USA.
Observationally-derived emissions of ozone depleting substances must be scrutinized to maintain the progress made by the Montreal Protocol in protecting the stratospheric ozone layer. Recent observations of three chlorofluorocarbons (CFCs), CFC-113, CFC-114, and CFC-115, suggest that emissions of these compounds have not decreased as expected given global reporting of their production. These emissions have been associated with hydrofluorocarbon (HFC) production, which can require CFCs as feedstocks or generate CFCs as by-products, yet emissions from these pathways have not been rigorously quantified.
View Article and Find Full Text PDFThe Cryo-EM structure of human CD163 bound to haptoglobin-hemoglobin reveals molecular mechanisms of hemoglobin scavenging.
Nat Commun
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Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.
CD163, a macrophage-specific receptor, plays a critical role in scavenging hemoglobin released during hemolysis, protecting against oxidative effects of heme iron. In the bloodstream, hemoglobin is bound by haptoglobin, leading to its immediate endocytosis by CD163. While haptoglobin's structure and function are well understood, CD163's structure and its interaction with the haptoglobin-hemoglobin complex have remained elusive.
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