Background: Posttraumatic stress disorder, a common psychiatric disorder in the general population, may follow a traumatic experience of awareness with recall during general anesthesia.
Methods: We conducted a matched cohort design with 9 subjects after intraoperative awareness with recall during general anesthesia. A psychiatric diagnostic interview and questionnaire were performed on 9 matched controls and 9 subjects, a median of 17.2 years from their documented awareness episode. The subjects and the matched controls completed a battery of questionnaires related to psychosocial well-being, after which they participated in a diagnostic Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders.
Results: Patients with awareness did not seem to differ from their matched controls in subsequent psychosocial outcome, psychiatric morbidity, or quality of life.
Conclusions: We found no indication that intraoperative awareness with recall had any deleterious long-term effects on patients' psychosocial outcome.
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http://dx.doi.org/10.1213/ANE.0000000000000257 | DOI Listing |
Bioinformatics
January 2025
Bioinformatics Lab, Advanced Research Institute for Informatics, Computing and Networking, De La Salle University, Manila, 1004, Philippines.
Motivation: Recent computational approaches for predicting phage-host interaction have explored the use of sequence-only protein language models to produce embeddings of phage proteins without manual feature engineering. However, these embeddings do not directly capture protein structure information and structure-informed signals related to host specificity.
Results: We present PHIStruct, a multilayer perceptron that takes in structure-aware embeddings of receptor-binding proteins, generated via the structure-aware protein language model SaProt, and then predicts the host from among the ESKAPEE genera.
BJA Open
March 2025
Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Background: Intraoperative awareness, without explicit recall, occurs after induction of anaesthesia in approximately 10% of persons under 40 yr of age. Most anaesthetic agents minimally suppress the noradrenergic system. We hypothesised that addition of dexmedetomidine, which suppresses noradrenergic activity, may reduce encephalographic (EEG) arousal in response to tracheal intubation; such an effect would lay the foundation for future studies of dexmedetomidine in reducing intraoperative awareness.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Computer Science and Engineering, BRAC University, Dhaka, Bangladesh.
Depression is more than just feeling sad. It is a severe and multifaceted mental health condition that impacts millions of individuals around the globe. Regrettably, it can even be more prevalent in university students of underdeveloped and developing countries like Bangladesh because of academic pressure, family and societal expectations, financial limitations, stigmatized social and cultural norms, unemployment concerns, lack of mental health awareness, etc.
View Article and Find Full Text PDFJMIR Form Res
January 2025
Department of Health Administration, The College of Health Professions, Central Michigan University, Mt Pleasant, MI, United States.
Insects
November 2024
School of Tropical Agriculture and Forestry, Hainan University, Danzhou 571737, China.
Powdery mildew has become a significant disease affecting the yield and quality of rubber trees in recent years. It typically manifests on the leaf surface at an early stage, rapidly infecting and spreading throughout the leaves. Therefore, early detection and intervention are essential to reduce the resulting losses due to this disease.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!