The aim of the present study was to investigate the distribution of CD4CD25 regulatory T cells (Tregs) in the peripheral blood of patients with chronic hepatitis C; in addition to identifying whether the distribution of CD4CD25 Tregs predicts the efficacy of antiviral therapy for HCV. The expression of CD4CD25 forkhead box protein (FOXP) 3 Tregs within a CD4 T cell population was detected in the peripheral blood obtained from patients with chronic hepatitis C and from healthy control subjects using flow cytometry. The hepatitis C virus (HCV)-RNA load was measured using quantitative-fluorescence polymerase chain reaction. CD4CD25FOXP3 Tregs accounted for 14.24±1.33% of the CD4 T cells in the peripheral blood of patients with chronic hepatitis C, which was higher than that of the healthy control subjects (5.62±1.21%; P<0.001). Furthermore, the frequency of CD4CD25FOXP3 Tregs in CD4 T cells of the peripheral blood positively correlated with the HCV-RNA load (r=0.73; P=0.032). Therefore, the results of the present study indicated that the expression of CD4CD25FOXP3 Tregs increased in patients that were chronically infected with HCV and positively correlated with the HCV-RNA load.
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| http://dx.doi.org/10.3892/etm.2014.1675 | DOI Listing |
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