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Mimics of pancreatic neoplasms at cross-sectional imaging: Pearls for characterization and diagnostic work-up.

Curr Probl Diagn Radiol

December 2024

Department of Diagnostic Radiology, Queen Elizabeth II Health Sciences Centre and Dalhousie University. Victoria General Building, 3rd floor, 1276 South Park Street, Halifax, Nova Scotia B3H 2Y9, Canada. Electronic address:

Interpreting imaging examinations of the pancreas can be a challenge. Several different entities can mimic or mask pancreatic neoplasms, including normal anatomic variants, non-pancreatic lesions, and both acute and chronic pancreatitis. It is important to distinguish these entities from pancreatic neoplasms, as the management and prognosis of a pancreatic neoplasm, particularly adenocarcinoma, have considerable impact on patients.

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Torsion of an accessory spleen is a rare condition, and it is often difficult to diagnose. It frequently presents as an acute abdomen, especially in young individuals. Only several dozen cases have been reported so far, and instances of rupture are even rarer.

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Castleman disease (CD) is a nonclonal lymphoproliferative disorder that causes non-neoplastic lymph node enlargement. With an incidence of approximately 21-25 cases per million, CD presents variably, often mimicking both benign and malignant conditions across various body regions. Clinically, it ranges from asymptomatic lymph node enlargement in Unicentric Castleman's Disease (UCD) to aggressive, multicentric presentations affecting multiple organs.

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Article Synopsis
  • The spleen develops from mesenchymal cells in the dorsal mesentery during embryogenesis, and accessory spleens are common anomalies that can be mistaken for tumors; this case is the first report of three accessory spleens found in Syria in a patient who had a prior splenectomy.
  • A 33-year-old male experienced right-sided abdominal pain, and after medical evaluation, imaging tests showed a lobulated mass in the right adrenal gland and elevated levels of metanephrine, suggesting a pheochromocytoma; laparoscopic surgery ultimately revealed multiple accessory spleens without signs of cancer.
  • The case emphasizes the importance of considering accessory spleens in patients with masses near the adrenal glands, as they can complicate diagnosis and treatment
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Reduction of antisense transcription affects bovine leukemia virus replication and oncogenesis.

PLoS Pathog

November 2024

Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), Sart-Tilman, Liège, Belgium; Molecular Biology, Teaching and Research Centre (TERRA), Gembloux, Belgium.

In sheep infected with bovine leukemia virus (BLV), transcription of structural, enzymatic, and accessory genes is silenced. However, the BLV provirus transcribes a series of non-coding RNAs that remain undetected by the host immune response. Specifically, three RNAs (AS1-L, AS1-S, and AS2) are consistently expressed from the antisense strand, originating from transcriptional initiation at the 3'-Long Terminal Repeat (LTR).

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